Maternal hypothyroidism during pregnancy alters the function of the retinol-binding protein 4-mediated mitochondrial permeability conversion pore in the kidneys of offspring rats

Maternal hypothyroidism during pregnancy alters the function of the retinol-binding protein 4-mediated mitochondrial permeability conversion pore in the kidneys of offspring rats

OBJECTIVES To determine the role of the RBP4/PiC/SIRT3 signaling pathway in the opening of the mitochondria permeability transition pore (mPTP) in offspring rats with hypothyroidism during pregnancy. METHODS Sixty Sprague-Dawley (SD) rats were employed in this study. Pregnancy was deemed successful...

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Bibliographic Details
Main Authors: Danyan Chen, Li Li, Fang Ren, Rongxi Huang, Hua Gan, Huacong Deng, Hongman Wang
Format: Article
Language:English
Published: Elsevier España 2021-01-01
Series:Clinics
Subjects:
Maternal Hypothyroidism
Pregnancy
Offspring
mPTP
RBP4/PiC/SIRT3 Pathway
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100218&tlng=en

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