Cleavage of the APE1 N-Terminal Domain in Acute Myeloid Leukemia Cells Is Associated with Proteasomal Activity

Cleavage of the APE1 N-Terminal Domain in Acute Myeloid Leukemia Cells Is Associated with Proteasomal Activity

Apurinic/apyrimidinic endonuclease 1 (APE1), the main mammalian AP-endonuclease for the resolution of DNA damages through the base excision repair (BER) pathway, acts as a multifunctional protein in different key cellular processes. The signals to ensure temporo-spatial regulation of APE1 towards a...

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Bibliographic Details
Main Authors: Lisa Lirussi, Giulia Antoniali, Pasqualina Liana Scognamiglio, Daniela Marasco, Emiliano Dalla, Chiara D’Ambrosio, Simona Arena, Andrea Scaloni, Gianluca Tell
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
apurinic apyrimidinic endonuclease/redox effector factor 1
cytoplasmic nucleophosmin 1
proteasome
acute myeloid leukemia
proteolysis
Online Access:https://www.mdpi.com/2218-273X/10/4/531

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