SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil
COVID-19 vaccination began in São Paulo, Brazil in January 2021, first targeting healthcare workers (HCWs) and the elderly, using the CoronaVac vaccine (Sinovac/Butantan) and subsequently the Oxford/AstraZeneca (ChAdOx1) vaccine (AstraZeneca/FIOCRUZ-RJ). Studies on such vaccines have shown efficacy...
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| Format: | Article |
| Language: | English |
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Pan American Health Organization
2021-10-01
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| Series: | Revista Panamericana de Salud Pública |
| Subjects: | |
| Online Access: | https://iris.paho.org/handle/10665.2/54838 |
| _version_ | 1818893699087597568 |
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| author | Karoline Rodrigues Campos Cláudio Tavares Sacchi Adriano Abbud Adele Caterino-de-Araujo |
| author_facet | Karoline Rodrigues Campos Cláudio Tavares Sacchi Adriano Abbud Adele Caterino-de-Araujo |
| author_sort | Karoline Rodrigues Campos |
| collection | DOAJ |
| description | COVID-19 vaccination began in São Paulo, Brazil in January 2021, first targeting healthcare workers (HCWs) and the elderly, using the CoronaVac vaccine (Sinovac/Butantan) and subsequently the Oxford/AstraZeneca (ChAdOx1) vaccine (AstraZeneca/FIOCRUZ-RJ). Studies on such vaccines have shown efficacy in preventing severe cases and deaths, but there is a lack of information regarding their effectiveness. This manuscript presents data from the Instituto Adolfo Lutz (IAL), a public health laboratory located in São Paulo City that receives samples from 17 Regional Health Departments under the Secretary of Health of São Paulo, for SARS-CoV-2 genomic surveillance. Through May 15, 2021 IAL received 20 samples for analysis from COVID-19 vaccinated individuals who needed hospitalization and/or died from COVID-19. Next-generation sequencing was performed on an Ion Torrent S5 platform using the AmpliSeq SARS-CoV-2 kit. Almost all cases were vaccinated with CoronaVac and presented the gamma variant of concern (VOC). Cases of death were observed mostly in the elderly in nursing homes, and severe cases in younger frontline HCWs. This data confirmed that the SARS-CoV-2 gamma variant is highly transmissible, severe, and lethal for COVID-19 in these groups of individuals, thereby highlighting the importance of continuous vaccination and non-pharmacological prevention measures to avoid virus dissemination and the emergence of new VOCs. |
| first_indexed | 2024-12-19T18:16:45Z |
| format | Article |
| id | doaj.art-9b18369cb36a478399a518bf795f2b5b |
| institution | Directory Open Access Journal |
| issn | 1020-4989 1680-5348 |
| language | English |
| last_indexed | 2024-12-19T18:16:45Z |
| publishDate | 2021-10-01 |
| publisher | Pan American Health Organization |
| record_format | Article |
| series | Revista Panamericana de Salud Pública |
| spelling | doaj.art-9b18369cb36a478399a518bf795f2b5b2022-12-21T20:11:05ZengPan American Health OrganizationRevista Panamericana de Salud Pública1020-49891680-53482021-10-01451261510.26633/RPSP.2021.126rpspSARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, BrazilKaroline Rodrigues Campos0Cláudio Tavares Sacchi1Adriano Abbud2Adele Caterino-de-Araujo3Laboratório Estratégico, Centro de Respostas Rápidas, Instituto Adolfo Lutz, São Paulo, SP, Brasil.Laboratório Estratégico, Centro de Respostas Rápidas, Instituto Adolfo Lutz, São Paulo, SP, Brasil.Centro de Respostas Rápidas, Instituto Adolfo Lutz, São Paulo, SP, Brasil.Centro de Imunologia, Instituto Adolfo Lutz, São Paulo, SP, BrasilCOVID-19 vaccination began in São Paulo, Brazil in January 2021, first targeting healthcare workers (HCWs) and the elderly, using the CoronaVac vaccine (Sinovac/Butantan) and subsequently the Oxford/AstraZeneca (ChAdOx1) vaccine (AstraZeneca/FIOCRUZ-RJ). Studies on such vaccines have shown efficacy in preventing severe cases and deaths, but there is a lack of information regarding their effectiveness. This manuscript presents data from the Instituto Adolfo Lutz (IAL), a public health laboratory located in São Paulo City that receives samples from 17 Regional Health Departments under the Secretary of Health of São Paulo, for SARS-CoV-2 genomic surveillance. Through May 15, 2021 IAL received 20 samples for analysis from COVID-19 vaccinated individuals who needed hospitalization and/or died from COVID-19. Next-generation sequencing was performed on an Ion Torrent S5 platform using the AmpliSeq SARS-CoV-2 kit. Almost all cases were vaccinated with CoronaVac and presented the gamma variant of concern (VOC). Cases of death were observed mostly in the elderly in nursing homes, and severe cases in younger frontline HCWs. This data confirmed that the SARS-CoV-2 gamma variant is highly transmissible, severe, and lethal for COVID-19 in these groups of individuals, thereby highlighting the importance of continuous vaccination and non-pharmacological prevention measures to avoid virus dissemination and the emergence of new VOCs.https://iris.paho.org/handle/10665.2/54838betacoronaviruscoronavirus infectionsvaccinescause of deathrisk groupsbrazil |
| spellingShingle | Karoline Rodrigues Campos Cláudio Tavares Sacchi Adriano Abbud Adele Caterino-de-Araujo SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil Revista Panamericana de Salud Pública betacoronavirus coronavirus infections vaccines cause of death risk groups brazil |
| title | SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
| title_full | SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
| title_fullStr | SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
| title_full_unstemmed | SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
| title_short | SARS-CoV-2 variants in severely symptomatic and deceased persons who had been vaccinated against COVID-19 in São Paulo, Brazil |
| title_sort | sars cov 2 variants in severely symptomatic and deceased persons who had been vaccinated against covid 19 in sao paulo brazil |
| topic | betacoronavirus coronavirus infections vaccines cause of death risk groups brazil |
| url | https://iris.paho.org/handle/10665.2/54838 |
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