The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition
STriatal-Enriched protein tyrosine Phosphatase (STEP) has recently been implicated in several neuropsychiatric disorders with significant cognitive impairments, including Alzheimer’s disease, schizophrenia, and fragile X syndrome. A model has emerged by which STEP normally opposes the development of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-07-01
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| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00047/full |
| _version_ | 1811208564121796608 |
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| author | Christopher James Fitzpatrick Paul J Lombroso Paul J Lombroso Paul J Lombroso Paul J Lombroso |
| author_facet | Christopher James Fitzpatrick Paul J Lombroso Paul J Lombroso Paul J Lombroso Paul J Lombroso |
| author_sort | Christopher James Fitzpatrick |
| collection | DOAJ |
| description | STriatal-Enriched protein tyrosine Phosphatase (STEP) has recently been implicated in several neuropsychiatric disorders with significant cognitive impairments, including Alzheimer’s disease, schizophrenia, and fragile X syndrome. A model has emerged by which STEP normally opposes the development of synaptic strengthening and that disruption in STEP activity leads to aberrant synaptic function. We review the mechanisms by which STEP contributes to the etiology of these and other neuropsychiatric disorders. These findings suggest that disruptions in STEP activity may be a common mechanism for cognitive impairments in diverse illnesses. |
| first_indexed | 2024-04-12T04:23:28Z |
| format | Article |
| id | doaj.art-9b198e81e3b44fefa4da2195c0ecf841 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-04-12T04:23:28Z |
| publishDate | 2011-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-9b198e81e3b44fefa4da2195c0ecf8412022-12-22T03:48:10ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292011-07-01510.3389/fnana.2011.0004711402The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognitionChristopher James Fitzpatrick0Paul J Lombroso1Paul J Lombroso2Paul J Lombroso3Paul J Lombroso4University of Michigan, Ann Arbor, MIYale University, New Haven, CTYale University, New Haven, CTYale University, New Haven, CTYale University, New Haven, CTSTriatal-Enriched protein tyrosine Phosphatase (STEP) has recently been implicated in several neuropsychiatric disorders with significant cognitive impairments, including Alzheimer’s disease, schizophrenia, and fragile X syndrome. A model has emerged by which STEP normally opposes the development of synaptic strengthening and that disruption in STEP activity leads to aberrant synaptic function. We review the mechanisms by which STEP contributes to the etiology of these and other neuropsychiatric disorders. These findings suggest that disruptions in STEP activity may be a common mechanism for cognitive impairments in diverse illnesses.http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00047/fullCognitionFragile X SyndromeSchizophreniaAlzheimer's diseaseHuntington's diseaseexcitotoxicity |
| spellingShingle | Christopher James Fitzpatrick Paul J Lombroso Paul J Lombroso Paul J Lombroso Paul J Lombroso The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition Frontiers in Neuroanatomy Cognition Fragile X Syndrome Schizophrenia Alzheimer's disease Huntington's disease excitotoxicity |
| title | The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition |
| title_full | The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition |
| title_fullStr | The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition |
| title_full_unstemmed | The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition |
| title_short | The role of STriatal-Enriched protein tyrosine Phosphastase (STEP) in cognition |
| title_sort | role of striatal enriched protein tyrosine phosphastase step in cognition |
| topic | Cognition Fragile X Syndrome Schizophrenia Alzheimer's disease Huntington's disease excitotoxicity |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00047/full |
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