Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat
IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015001975 |
| _version_ | 1817995350489694208 |
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| author | Scott P. Commins Maya R. Jerath Kelly Cox Loren D. Erickson Thomas Platts-Mills |
| author_facet | Scott P. Commins Maya R. Jerath Kelly Cox Loren D. Erickson Thomas Platts-Mills |
| author_sort | Scott P. Commins |
| collection | DOAJ |
| description | IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term risk reduction. As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation and management of patients with idiopathic anaphylaxis. Within the last 10 years several apparently separate observations were recognized to be related, all of which resulted from the development of antibodies to a carbohydrate moiety on proteins. Interestingly, the exposure differed from airborne allergens but was nevertheless capable of producing anaphylactic and hypersensitivity reactions. Our recent work has identified these responses as being due to a novel IgE antibody directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (“alpha-gal”). This review will present the historical summary of the identification of cetuximab hypersensitivity due to alpha-gal IgE and discuss the non-primate mammalian meat food allergy as well as current goals and directions of our research programs. |
| first_indexed | 2024-04-14T02:04:51Z |
| format | Article |
| id | doaj.art-9b1a53636f59460288577737d580ba64 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-14T02:04:51Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-9b1a53636f59460288577737d580ba642022-12-22T02:18:42ZengElsevierAllergology International1323-89302016-01-01651162010.1016/j.alit.2015.10.001Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meatScott P. Commins0Maya R. Jerath1Kelly Cox2Loren D. Erickson3Thomas Platts-Mills4Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USADepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USADepartment of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USADepartment of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USADepartment of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USAIgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term risk reduction. As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation and management of patients with idiopathic anaphylaxis. Within the last 10 years several apparently separate observations were recognized to be related, all of which resulted from the development of antibodies to a carbohydrate moiety on proteins. Interestingly, the exposure differed from airborne allergens but was nevertheless capable of producing anaphylactic and hypersensitivity reactions. Our recent work has identified these responses as being due to a novel IgE antibody directed against a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (“alpha-gal”). This review will present the historical summary of the identification of cetuximab hypersensitivity due to alpha-gal IgE and discuss the non-primate mammalian meat food allergy as well as current goals and directions of our research programs.http://www.sciencedirect.com/science/article/pii/S1323893015001975Alpha-galDelayed anaphylaxisGlycanIgERed meat allergy |
| spellingShingle | Scott P. Commins Maya R. Jerath Kelly Cox Loren D. Erickson Thomas Platts-Mills Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat Allergology International Alpha-gal Delayed anaphylaxis Glycan IgE Red meat allergy |
| title | Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat |
| title_full | Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat |
| title_fullStr | Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat |
| title_full_unstemmed | Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat |
| title_short | Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat |
| title_sort | delayed anaphylaxis to alpha gal an oligosaccharide in mammalian meat |
| topic | Alpha-gal Delayed anaphylaxis Glycan IgE Red meat allergy |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015001975 |
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