Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial
IntroductionPeriodontal disease is a ubiquitous disease in small animal veterinary medicine. Currently regular professional dental cleaning and daily tooth brushing are considered gold standards in the prevention of periodontal disease. Efforts to find a noninvasive, cost effective and easy to use p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1255834/full |
| _version_ | 1827811881320972288 |
|---|---|
| author | Amarett Kern Tammy (White) Renteria Marilynn L. Rothen Lloyd A. Mancl Peter Milgrom |
| author_facet | Amarett Kern Tammy (White) Renteria Marilynn L. Rothen Lloyd A. Mancl Peter Milgrom |
| author_sort | Amarett Kern |
| collection | DOAJ |
| description | IntroductionPeriodontal disease is a ubiquitous disease in small animal veterinary medicine. Currently regular professional dental cleaning and daily tooth brushing are considered gold standards in the prevention of periodontal disease. Efforts to find a noninvasive, cost effective and easy to use preventative for periodontal disease are ongoing. The primary objective of this double-blind randomized clinical trial was to determine if a single application of silver diamine fluoride (SDF) 38% on the buccal surface of all teeth would reduce gingivitis within 3 months in dogs with stage two periodontal disease.MethodsTwenty-nine client-owned dogs 3–12 years old, 6–35 pounds were randomized 1:1 into active and placebo-control groups. Both groups underwent a baseline treatment and a three-month follow-up under general anesthesia. Gingival Index (GI), Plaque Index (PI), and Calculus Index (CI) were assessed and recorded at each event.ResultsA single application of SDF 38% did not significantly lower GI relative to the control group. However, the GI score dropped significantly in both groups relative to baseline, with a 53% reduction in the average GI score for dogs that received SDF 38% treatment and a 44% reduction for dogs that received placebo treatment. There were no differences in PI or CI scores compared to control groups.ConclusionFurther research is needed to determine if a more frequent application or a longer study duration would yield a different outcome. |
| first_indexed | 2024-03-11T23:11:42Z |
| format | Article |
| id | doaj.art-9b1ce9c1f2184ddab833008c39903697 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-11T23:11:42Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-9b1ce9c1f2184ddab833008c399036972023-09-21T08:36:05ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-09-011010.3389/fvets.2023.12558341255834Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trialAmarett Kern0Tammy (White) Renteria1Marilynn L. Rothen2Lloyd A. Mancl3Peter Milgrom4Inland Northwest Veterinary Dentistry and Oral Surgery, Coeur d’Alene, ID, United StatesInland Northwest Veterinary Dentistry and Oral Surgery, Coeur d’Alene, ID, United StatesSchool of Dentistry and Research Implementation Manager, Institute of Translational Health Sciences Regional Clinical Dental Research Center, University of Washington, Seattle, WA, United StatesDepartment of Oral Health Sciences, University of Washington, Seattle, WA, United StatesDepartment of Oral Health Sciences, University of Washington, Seattle, WA, United StatesIntroductionPeriodontal disease is a ubiquitous disease in small animal veterinary medicine. Currently regular professional dental cleaning and daily tooth brushing are considered gold standards in the prevention of periodontal disease. Efforts to find a noninvasive, cost effective and easy to use preventative for periodontal disease are ongoing. The primary objective of this double-blind randomized clinical trial was to determine if a single application of silver diamine fluoride (SDF) 38% on the buccal surface of all teeth would reduce gingivitis within 3 months in dogs with stage two periodontal disease.MethodsTwenty-nine client-owned dogs 3–12 years old, 6–35 pounds were randomized 1:1 into active and placebo-control groups. Both groups underwent a baseline treatment and a three-month follow-up under general anesthesia. Gingival Index (GI), Plaque Index (PI), and Calculus Index (CI) were assessed and recorded at each event.ResultsA single application of SDF 38% did not significantly lower GI relative to the control group. However, the GI score dropped significantly in both groups relative to baseline, with a 53% reduction in the average GI score for dogs that received SDF 38% treatment and a 44% reduction for dogs that received placebo treatment. There were no differences in PI or CI scores compared to control groups.ConclusionFurther research is needed to determine if a more frequent application or a longer study duration would yield a different outcome.https://www.frontiersin.org/articles/10.3389/fvets.2023.1255834/fullsilver diamine fluoridegingivitisplaque indexperiodontal disease preventiondog |
| spellingShingle | Amarett Kern Tammy (White) Renteria Marilynn L. Rothen Lloyd A. Mancl Peter Milgrom Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial Frontiers in Veterinary Science silver diamine fluoride gingivitis plaque index periodontal disease prevention dog |
| title | Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial |
| title_full | Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial |
| title_fullStr | Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial |
| title_full_unstemmed | Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial |
| title_short | Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial |
| title_sort | effectiveness of silver diamine fluoride 38 on reduction of gingivitis in dogs a randomized clinical trial |
| topic | silver diamine fluoride gingivitis plaque index periodontal disease prevention dog |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1255834/full |
| work_keys_str_mv | AT amarettkern effectivenessofsilverdiaminefluoride38onreductionofgingivitisindogsarandomizedclinicaltrial AT tammywhiterenteria effectivenessofsilverdiaminefluoride38onreductionofgingivitisindogsarandomizedclinicaltrial AT marilynnlrothen effectivenessofsilverdiaminefluoride38onreductionofgingivitisindogsarandomizedclinicaltrial AT lloydamancl effectivenessofsilverdiaminefluoride38onreductionofgingivitisindogsarandomizedclinicaltrial AT petermilgrom effectivenessofsilverdiaminefluoride38onreductionofgingivitisindogsarandomizedclinicaltrial |