Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets.
The whipworm, Trichuris trichiura, causes trichuriasis in ∼600 million people worldwide, mainly in developing countries. Whipworms also infect other animal hosts, including pigs (T. suis), dogs (T. vulpis) and non-human primates, and cause disease in these hosts, which is similar to trichuriasis of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC3283558?pdf=render |
| _version_ | 1811208056169562112 |
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| author | Guo-Hua Liu Robin B Gasser Ang Su Peter Nejsum Lifei Peng Rui-Qing Lin Ming-Wei Li Min-Jun Xu Xing-Quan Zhu |
| author_facet | Guo-Hua Liu Robin B Gasser Ang Su Peter Nejsum Lifei Peng Rui-Qing Lin Ming-Wei Li Min-Jun Xu Xing-Quan Zhu |
| author_sort | Guo-Hua Liu |
| collection | DOAJ |
| description | The whipworm, Trichuris trichiura, causes trichuriasis in ∼600 million people worldwide, mainly in developing countries. Whipworms also infect other animal hosts, including pigs (T. suis), dogs (T. vulpis) and non-human primates, and cause disease in these hosts, which is similar to trichuriasis of humans. Although Trichuris species are considered to be host specific, there has been considerable controversy, over the years, as to whether T. trichiura and T. suis are the same or distinct species. Here, we characterised the entire mitochondrial genomes of human-derived Trichuris and pig-derived Trichuris, compared them and then tested the hypothesis that the parasites from these two host species are genetically distinct in a phylogenetic analysis of the sequence data. Taken together, the findings support the proposal that T. trichiura and T. suis are separate species, consistent with previous data for nuclear ribosomal DNA. Using molecular analytical tools, employing genetic markers defined herein, future work should conduct large-scale studies to establish whether T. trichiura is found in pigs and T. suis in humans in endemic regions. |
| first_indexed | 2024-04-12T04:15:56Z |
| format | Article |
| id | doaj.art-9b1d62d4069e49ea8ebcc66b9902c03a |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-12T04:15:56Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-9b1d62d4069e49ea8ebcc66b9902c03a2022-12-22T03:48:25ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352012-01-0162e153910.1371/journal.pntd.0001539Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets.Guo-Hua LiuRobin B GasserAng SuPeter NejsumLifei PengRui-Qing LinMing-Wei LiMin-Jun XuXing-Quan ZhuThe whipworm, Trichuris trichiura, causes trichuriasis in ∼600 million people worldwide, mainly in developing countries. Whipworms also infect other animal hosts, including pigs (T. suis), dogs (T. vulpis) and non-human primates, and cause disease in these hosts, which is similar to trichuriasis of humans. Although Trichuris species are considered to be host specific, there has been considerable controversy, over the years, as to whether T. trichiura and T. suis are the same or distinct species. Here, we characterised the entire mitochondrial genomes of human-derived Trichuris and pig-derived Trichuris, compared them and then tested the hypothesis that the parasites from these two host species are genetically distinct in a phylogenetic analysis of the sequence data. Taken together, the findings support the proposal that T. trichiura and T. suis are separate species, consistent with previous data for nuclear ribosomal DNA. Using molecular analytical tools, employing genetic markers defined herein, future work should conduct large-scale studies to establish whether T. trichiura is found in pigs and T. suis in humans in endemic regions.http://europepmc.org/articles/PMC3283558?pdf=render |
| spellingShingle | Guo-Hua Liu Robin B Gasser Ang Su Peter Nejsum Lifei Peng Rui-Qing Lin Ming-Wei Li Min-Jun Xu Xing-Quan Zhu Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets. PLoS Neglected Tropical Diseases |
| title | Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets. |
| title_full | Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets. |
| title_fullStr | Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets. |
| title_full_unstemmed | Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets. |
| title_short | Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets. |
| title_sort | clear genetic distinctiveness between human and pig derived trichuris based on analyses of mitochondrial datasets |
| url | http://europepmc.org/articles/PMC3283558?pdf=render |
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