Signaling and regulation of G protein-coupled receptors in airway smooth muscle
<p>Abstract</p> <p>Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2003-03-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1186/1465-9921-4-2 |
| _version_ | 1818347830827286528 |
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| author | Penn Raymond B Billington Charlotte K |
| author_facet | Penn Raymond B Billington Charlotte K |
| author_sort | Penn Raymond B |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.</p> |
| first_indexed | 2024-12-13T17:40:24Z |
| format | Article |
| id | doaj.art-9b1d85ada07c4b47a800c6a4d8884c60 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-13T17:40:24Z |
| publishDate | 2003-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-9b1d85ada07c4b47a800c6a4d8884c602022-12-21T23:36:47ZengBMCRespiratory Research1465-99212003-03-0141210.1186/1465-9921-4-2Signaling and regulation of G protein-coupled receptors in airway smooth musclePenn Raymond BBillington Charlotte K<p>Abstract</p> <p>Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.</p>http://dx.doi.org/10.1186/1465-9921-4-2G protein-coupled receptorairway smooth muscleinflammationsynthetic functionairway remodeling |
| spellingShingle | Penn Raymond B Billington Charlotte K Signaling and regulation of G protein-coupled receptors in airway smooth muscle Respiratory Research G protein-coupled receptor airway smooth muscle inflammation synthetic function airway remodeling |
| title | Signaling and regulation of G protein-coupled receptors in airway smooth muscle |
| title_full | Signaling and regulation of G protein-coupled receptors in airway smooth muscle |
| title_fullStr | Signaling and regulation of G protein-coupled receptors in airway smooth muscle |
| title_full_unstemmed | Signaling and regulation of G protein-coupled receptors in airway smooth muscle |
| title_short | Signaling and regulation of G protein-coupled receptors in airway smooth muscle |
| title_sort | signaling and regulation of g protein coupled receptors in airway smooth muscle |
| topic | G protein-coupled receptor airway smooth muscle inflammation synthetic function airway remodeling |
| url | http://dx.doi.org/10.1186/1465-9921-4-2 |
| work_keys_str_mv | AT pennraymondb signalingandregulationofgproteincoupledreceptorsinairwaysmoothmuscle AT billingtoncharlottek signalingandregulationofgproteincoupledreceptorsinairwaysmoothmuscle |