Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region
Abstract Objective Similar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial...
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| Format: | Article |
| Language: | English |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2023-10-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000800474&lng=en&tlng=en |
| _version_ | 1797662813566533632 |
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| author | Luís Felipe Leite Martins Miguel Ângelo Martins Moreira Rodrigo Alves Pinto Neilane Bertoni dos Reis Shayany Pinto Felix João Paulo Castello Branco Vidal Leuridan Cavalcante Torres Ariani Impieri Souza Liz Maria de Almeida |
| author_facet | Luís Felipe Leite Martins Miguel Ângelo Martins Moreira Rodrigo Alves Pinto Neilane Bertoni dos Reis Shayany Pinto Felix João Paulo Castello Branco Vidal Leuridan Cavalcante Torres Ariani Impieri Souza Liz Maria de Almeida |
| author_sort | Luís Felipe Leite Martins |
| collection | DOAJ |
| description | Abstract Objective Similar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer. The present study aimed to analyze the genetic diversity of the HPV16 genotype in women with CIN2/CIN3 and cervical cancer, from the northeast region of Brazil. Methods A cross-sectional multicenter study was conducted in the northeast region of Brazil, from 2014 to 2016. This study included 196 cases of HPV16 variants (59 and 137 cases of CIN2/CIN3 and cervical cancer, respectively). The difference of proportion test was used to compare patients with CIN2/CIN3 and cervical cancer, based on the prevalent HPV16 lineage (p < 0.05). Results According to the histopathological diagnosis, the percentage of lineage frequencies revealed a marginal difference in the prevalence of lineage A in CIN2/CIN3, compared with that in cervical cancer (p = 0.053). For lineage D, the proportion was higher in cancer cases (32.8%), than in CIN2/CIN3 cases (16.9%), with p = 0.023. Conclusion HPV16 lineage A was the most frequent lineage in both CIN2/CIN3 and cervical cancer samples, while lineage D was predominant in cervical cancer, suggesting a possible association between HPV16 lineage D and cervical cancer. |
| first_indexed | 2024-03-11T19:05:31Z |
| format | Article |
| id | doaj.art-9b1ec33072d4454eb63de2a89571f839 |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-03-11T19:05:31Z |
| publishDate | 2023-10-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-9b1ec33072d4454eb63de2a89571f8392023-10-10T07:45:25ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032023-10-0145847447910.1055/s-0043-1772180Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast RegionLuís Felipe Leite Martinshttps://orcid.org/0000-0001-5016-8459Miguel Ângelo Martins Moreirahttps://orcid.org/0000-0003-1437-7522Rodrigo Alves Pintohttps://orcid.org/0000-0003-0492-7316Neilane Bertoni dos Reishttps://orcid.org/0000-0002-2539-9965Shayany Pinto Felixhttps://orcid.org/0000-0003-2209-8961João Paulo Castello Branco Vidalhttps://orcid.org/0000-0002-2984-8131Leuridan Cavalcante Torreshttps://orcid.org/0000-0003-3517-6615Ariani Impieri Souzahttps://orcid.org/0000-0002-7917-5983Liz Maria de Almeidahttps://orcid.org/0000-0002-2359-0651Abstract Objective Similar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer. The present study aimed to analyze the genetic diversity of the HPV16 genotype in women with CIN2/CIN3 and cervical cancer, from the northeast region of Brazil. Methods A cross-sectional multicenter study was conducted in the northeast region of Brazil, from 2014 to 2016. This study included 196 cases of HPV16 variants (59 and 137 cases of CIN2/CIN3 and cervical cancer, respectively). The difference of proportion test was used to compare patients with CIN2/CIN3 and cervical cancer, based on the prevalent HPV16 lineage (p < 0.05). Results According to the histopathological diagnosis, the percentage of lineage frequencies revealed a marginal difference in the prevalence of lineage A in CIN2/CIN3, compared with that in cervical cancer (p = 0.053). For lineage D, the proportion was higher in cancer cases (32.8%), than in CIN2/CIN3 cases (16.9%), with p = 0.023. Conclusion HPV16 lineage A was the most frequent lineage in both CIN2/CIN3 and cervical cancer samples, while lineage D was predominant in cervical cancer, suggesting a possible association between HPV16 lineage D and cervical cancer.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000800474&lng=en&tlng=enHPV16lineage Alineage DCIN2/CIN3cervical cancer |
| spellingShingle | Luís Felipe Leite Martins Miguel Ângelo Martins Moreira Rodrigo Alves Pinto Neilane Bertoni dos Reis Shayany Pinto Felix João Paulo Castello Branco Vidal Leuridan Cavalcante Torres Ariani Impieri Souza Liz Maria de Almeida Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region Revista Brasileira de Ginecologia e Obstetrícia HPV16 lineage A lineage D CIN2/CIN3 cervical cancer |
| title | Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region |
| title_full | Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region |
| title_fullStr | Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region |
| title_full_unstemmed | Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region |
| title_short | Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region |
| title_sort | human papillomavirus 16 lineage d is associated with high risk of cervical cancer in the brazilian northeast region |
| topic | HPV16 lineage A lineage D CIN2/CIN3 cervical cancer |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032023000800474&lng=en&tlng=en |
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