Cerebrolysin Use in Patients with Liver Damage—A Translational Study
The treatment of acute life-threatening events in patients suffering from chronic pathologies is problematic, as physicians need to consider multisystemic drug effects. Regarding Cerebrolysin, a Sonic Hedgehog signaling pathway amplifier and one of the few approved neurotrophic treatments for stroke...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/11/1791 |
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| author | Shandiz Morega Andrei Gresita Smaranda Ioana Mitran Madalina Iuliana Musat Ianis Kevyn Stefan Boboc Victor Gheorman Ion Udristoiu Carmen Valeria Albu Costin Teodor Streba Bogdan Catalin Ion Rogoveanu |
| author_facet | Shandiz Morega Andrei Gresita Smaranda Ioana Mitran Madalina Iuliana Musat Ianis Kevyn Stefan Boboc Victor Gheorman Ion Udristoiu Carmen Valeria Albu Costin Teodor Streba Bogdan Catalin Ion Rogoveanu |
| author_sort | Shandiz Morega |
| collection | DOAJ |
| description | The treatment of acute life-threatening events in patients suffering from chronic pathologies is problematic, as physicians need to consider multisystemic drug effects. Regarding Cerebrolysin, a Sonic Hedgehog signaling pathway amplifier and one of the few approved neurotrophic treatments for stroke patients, concerns of excessive Hedgehog pathway activation that could accelerate NAFLD progression to cirrhosis seem valid. We investigated stroke patients treated with Cerebrolysin that presented elevated levels of aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT). We also investigated the efficiency of Cerebrolysin in reversing the neurogenesis inhibition within the hippocampus in a mouse model of NAFLD by evaluating behavior and histological outcomes. NeuN, BrdU and Iba1 positive signals in the cortex and hippocampus of the animals were also observed. Clinically, Cerebrolysin improved AST levels in a majority of stroke patients with hepatic damage. The same treatment in an experimental setup was able to reverse anxiety-like behavior in MCD mice, reducing their freezing time from 333.61 ± 21.81 s in MCD animals to 229.17 ± 26.28 in treated ones. The use of Cerebrolysin did not improve short-term memory nor rescued cell multiplication in the hippocampus after MCD food intake. Understanding the neuroprotective and neurotrophic effects that drugs have on NAFLD patients can significantly contribute to a suitable therapeutic approach. |
| first_indexed | 2024-03-09T18:54:59Z |
| format | Article |
| id | doaj.art-9b1ef24514a84fd5b3f58af1edbcb678 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T18:54:59Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-9b1ef24514a84fd5b3f58af1edbcb6782023-11-24T05:31:00ZengMDPI AGLife2075-17292022-11-011211179110.3390/life12111791Cerebrolysin Use in Patients with Liver Damage—A Translational StudyShandiz Morega0Andrei Gresita1Smaranda Ioana Mitran2Madalina Iuliana Musat3Ianis Kevyn Stefan Boboc4Victor Gheorman5Ion Udristoiu6Carmen Valeria Albu7Costin Teodor Streba8Bogdan Catalin9Ion Rogoveanu10U.M.F. Doctoral School Craiova, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Psychiatry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Psychiatry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Neurology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaResearch Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaGastroenterology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaThe treatment of acute life-threatening events in patients suffering from chronic pathologies is problematic, as physicians need to consider multisystemic drug effects. Regarding Cerebrolysin, a Sonic Hedgehog signaling pathway amplifier and one of the few approved neurotrophic treatments for stroke patients, concerns of excessive Hedgehog pathway activation that could accelerate NAFLD progression to cirrhosis seem valid. We investigated stroke patients treated with Cerebrolysin that presented elevated levels of aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT). We also investigated the efficiency of Cerebrolysin in reversing the neurogenesis inhibition within the hippocampus in a mouse model of NAFLD by evaluating behavior and histological outcomes. NeuN, BrdU and Iba1 positive signals in the cortex and hippocampus of the animals were also observed. Clinically, Cerebrolysin improved AST levels in a majority of stroke patients with hepatic damage. The same treatment in an experimental setup was able to reverse anxiety-like behavior in MCD mice, reducing their freezing time from 333.61 ± 21.81 s in MCD animals to 229.17 ± 26.28 in treated ones. The use of Cerebrolysin did not improve short-term memory nor rescued cell multiplication in the hippocampus after MCD food intake. Understanding the neuroprotective and neurotrophic effects that drugs have on NAFLD patients can significantly contribute to a suitable therapeutic approach.https://www.mdpi.com/2075-1729/12/11/1791NAFLDliver damageanxietyCerebrolysinneurogenesis |
| spellingShingle | Shandiz Morega Andrei Gresita Smaranda Ioana Mitran Madalina Iuliana Musat Ianis Kevyn Stefan Boboc Victor Gheorman Ion Udristoiu Carmen Valeria Albu Costin Teodor Streba Bogdan Catalin Ion Rogoveanu Cerebrolysin Use in Patients with Liver Damage—A Translational Study Life NAFLD liver damage anxiety Cerebrolysin neurogenesis |
| title | Cerebrolysin Use in Patients with Liver Damage—A Translational Study |
| title_full | Cerebrolysin Use in Patients with Liver Damage—A Translational Study |
| title_fullStr | Cerebrolysin Use in Patients with Liver Damage—A Translational Study |
| title_full_unstemmed | Cerebrolysin Use in Patients with Liver Damage—A Translational Study |
| title_short | Cerebrolysin Use in Patients with Liver Damage—A Translational Study |
| title_sort | cerebrolysin use in patients with liver damage a translational study |
| topic | NAFLD liver damage anxiety Cerebrolysin neurogenesis |
| url | https://www.mdpi.com/2075-1729/12/11/1791 |
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