SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF BENZYL ALCOHOL DERIVATIVES
Benzyl alcohol derivatives were synthesized, and characterized using NMR and FTIR spectroscopic techniques. For the first time, the antibacterial activities of the synthesized compounds were examined using disc diffusion method by measuring the diameter of the zones of inhibition against Staphylococ...
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| Format: | Article |
| Language: | English |
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Turkish Chemical Society
2020-06-01
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| Series: | Journal of the Turkish Chemical Society, Section A: Chemistry |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/pub/jotcsa/issue/52506/692113 |
| _version_ | 1797915244884918272 |
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| author | Mamman SULAIMAN Yusuf HASSAN Tugba TASKİN TOK Xavier Siwe NOUNDOU |
| author_facet | Mamman SULAIMAN Yusuf HASSAN Tugba TASKİN TOK Xavier Siwe NOUNDOU |
| author_sort | Mamman SULAIMAN |
| collection | DOAJ |
| description | Benzyl alcohol derivatives were synthesized, and characterized using NMR and FTIR spectroscopic techniques. For the first time, the antibacterial activities of the synthesized compounds were examined using disc diffusion method by measuring the diameter of the zones of inhibition against Staphylococcus aureus and Pseudomonas aeruginosa. The results demonstrated that the activity was concentration dependant, and that the compounds were generally potent against P. aeruginosa. Only two of the compounds were active against S. aureus. In terms of broad spectrum activity, compound 2d (35 mm) was found to exhibit a promising efficacy which surpassed that of the standard drug (amoxicillin).The binding of compounds 2a-e to the glucosamine-6-phosphate synthase (GlcN-6-P) active-site revealed that all the synthesized compounds fitted into the GlcN-6-P active-site receptor cavity, exhibited potential hydrogen-bonding interactions with the proximal amino acid residues and aligned similar to amoxicillin. Interestingly, it has been found that the most active compound, 2d also appeared to have a relatively low binding energy (-52.8901 kcal/mol). |
| first_indexed | 2024-04-10T12:38:38Z |
| format | Article |
| id | doaj.art-9b1f532f7d8644a599db2755afc90340 |
| institution | Directory Open Access Journal |
| issn | 2149-0120 |
| language | English |
| last_indexed | 2024-04-10T12:38:38Z |
| publishDate | 2020-06-01 |
| publisher | Turkish Chemical Society |
| record_format | Article |
| series | Journal of the Turkish Chemical Society, Section A: Chemistry |
| spelling | doaj.art-9b1f532f7d8644a599db2755afc903402023-02-15T16:14:25ZengTurkish Chemical SocietyJournal of the Turkish Chemical Society, Section A: Chemistry2149-01202020-06-017248148810.18596/jotcsa.692113SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF BENZYL ALCOHOL DERIVATIVESMamman SULAIMAN0Yusuf HASSAN1https://orcid.org/0000-0001-6117-2357Tugba TASKİN TOK2https://orcid.org/0000-0002-0064-8400Xavier Siwe NOUNDOU3https://orcid.org/0000-0002-8667-8351Umaru Musa Yar’adua University, NigeriaUmaru Musa Yar’adua University, NigeriaGaziantep Univesity, Faculty of Arts and Sciences, TurkeyRhodes University, Faculty of Science, Department of ChemistryBenzyl alcohol derivatives were synthesized, and characterized using NMR and FTIR spectroscopic techniques. For the first time, the antibacterial activities of the synthesized compounds were examined using disc diffusion method by measuring the diameter of the zones of inhibition against Staphylococcus aureus and Pseudomonas aeruginosa. The results demonstrated that the activity was concentration dependant, and that the compounds were generally potent against P. aeruginosa. Only two of the compounds were active against S. aureus. In terms of broad spectrum activity, compound 2d (35 mm) was found to exhibit a promising efficacy which surpassed that of the standard drug (amoxicillin).The binding of compounds 2a-e to the glucosamine-6-phosphate synthase (GlcN-6-P) active-site revealed that all the synthesized compounds fitted into the GlcN-6-P active-site receptor cavity, exhibited potential hydrogen-bonding interactions with the proximal amino acid residues and aligned similar to amoxicillin. Interestingly, it has been found that the most active compound, 2d also appeared to have a relatively low binding energy (-52.8901 kcal/mol).https://dergipark.org.tr/tr/pub/jotcsa/issue/52506/692113vanillyl alcoholantibacterial activitydocking studiesglucosamine-6-phosphate synthase |
| spellingShingle | Mamman SULAIMAN Yusuf HASSAN Tugba TASKİN TOK Xavier Siwe NOUNDOU SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF BENZYL ALCOHOL DERIVATIVES Journal of the Turkish Chemical Society, Section A: Chemistry vanillyl alcohol antibacterial activity docking studies glucosamine-6-phosphate synthase |
| title | SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF BENZYL ALCOHOL DERIVATIVES |
| title_full | SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF BENZYL ALCOHOL DERIVATIVES |
| title_fullStr | SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF BENZYL ALCOHOL DERIVATIVES |
| title_full_unstemmed | SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF BENZYL ALCOHOL DERIVATIVES |
| title_short | SYNTHESIS, ANTIBACTERIAL ACTIVITY AND DOCKING STUDIES OF BENZYL ALCOHOL DERIVATIVES |
| title_sort | synthesis antibacterial activity and docking studies of benzyl alcohol derivatives |
| topic | vanillyl alcohol antibacterial activity docking studies glucosamine-6-phosphate synthase |
| url | https://dergipark.org.tr/tr/pub/jotcsa/issue/52506/692113 |
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