19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage.
Diterpenoids jolkinolide A and B, were first isolated from Euphorbia fischeriana. In our previous research, 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), a derivative of jolkinolides, was synthesized as a novel ent -abietane diterpene diepoxide. In this study, 19-BJB showed strong in vitro activity a...
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248468&type=printable |
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| author | Ke Wang Juan-Cheng Yang Yeong-Jiunn Jang Guan-Yu Chen Ya-Jing Zhang Yun-Hao Dai Da-Yong Zhang Yang-Chang Wu |
| author_facet | Ke Wang Juan-Cheng Yang Yeong-Jiunn Jang Guan-Yu Chen Ya-Jing Zhang Yun-Hao Dai Da-Yong Zhang Yang-Chang Wu |
| author_sort | Ke Wang |
| collection | DOAJ |
| description | Diterpenoids jolkinolide A and B, were first isolated from Euphorbia fischeriana. In our previous research, 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), a derivative of jolkinolides, was synthesized as a novel ent -abietane diterpene diepoxide. In this study, 19-BJB showed strong in vitro activity against bladder cancer cell lines. DNA damage which was observed through the interaction of 19-BJB with nucleotide chains and affected DNA repair resulted in the activation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) in bladder cancer cell lines. In vivo testing in nude mice also proved that 19-BJB revealed a potential inhibitory effect on tumor growth. Additionally, the 3D-QSAR models of jolkinolides were established. Briefly, we proved that 19-BJB could potentially be used as a drug to inhibit the growth of bladder tumor. |
| first_indexed | 2024-12-21T07:41:51Z |
| format | Article |
| id | doaj.art-9b212d1ef9d24d4298ec9d9050443259 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T07:38:53Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-9b212d1ef9d24d4298ec9d90504432592025-03-03T05:36:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01163e024846810.1371/journal.pone.024846819-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage.Ke WangJuan-Cheng YangYeong-Jiunn JangGuan-Yu ChenYa-Jing ZhangYun-Hao DaiDa-Yong ZhangYang-Chang WuDiterpenoids jolkinolide A and B, were first isolated from Euphorbia fischeriana. In our previous research, 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), a derivative of jolkinolides, was synthesized as a novel ent -abietane diterpene diepoxide. In this study, 19-BJB showed strong in vitro activity against bladder cancer cell lines. DNA damage which was observed through the interaction of 19-BJB with nucleotide chains and affected DNA repair resulted in the activation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) in bladder cancer cell lines. In vivo testing in nude mice also proved that 19-BJB revealed a potential inhibitory effect on tumor growth. Additionally, the 3D-QSAR models of jolkinolides were established. Briefly, we proved that 19-BJB could potentially be used as a drug to inhibit the growth of bladder tumor.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248468&type=printable |
| spellingShingle | Ke Wang Juan-Cheng Yang Yeong-Jiunn Jang Guan-Yu Chen Ya-Jing Zhang Yun-Hao Dai Da-Yong Zhang Yang-Chang Wu 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage. PLoS ONE |
| title | 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage. |
| title_full | 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage. |
| title_fullStr | 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage. |
| title_full_unstemmed | 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage. |
| title_short | 19-(Benzyloxy)-19-oxojolkinolide B (19-BJB), an ent-abietane diterpene diepoxide, inhibits the growth of bladder cancer T24 cells through DNA damage. |
| title_sort | 19 benzyloxy 19 oxojolkinolide b 19 bjb an ent abietane diterpene diepoxide inhibits the growth of bladder cancer t24 cells through dna damage |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0248468&type=printable |
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