From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective [version 1; referees: 2 approved]
A variety of rodent models of hepatoprotection have been developed in which tolerance to acetaminophen-induced hepatotoxicity occurs. Autoprotection/heteroprotection is a phenomenon where prior exposure to a mildly toxic dose of toxicant confers protection against a subsequently administered higher...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2016-07-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/5-1698/v1 |
| _version_ | 1818506067389186048 |
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| author | Swetha Rudraiah José E. Manautou |
| author_facet | Swetha Rudraiah José E. Manautou |
| author_sort | Swetha Rudraiah |
| collection | DOAJ |
| description | A variety of rodent models of hepatoprotection have been developed in which tolerance to acetaminophen-induced hepatotoxicity occurs. Autoprotection/heteroprotection is a phenomenon where prior exposure to a mildly toxic dose of toxicant confers protection against a subsequently administered higher dose of the same toxicant (as in the case of autoprotection) or to a different toxicant (referred to as heteroprotection). Multiple mechanisms regulate this adaptive response, including hepatocellular proliferation, proteostasis, enhanced expression of cytoprotective genes, and altered tissue immune response. In this review, we will discuss recent findings that highlight the complexity of these adaptive mechanisms and we also outline the usefulness of these findings to devise therapeutic and/or diagnostic tools for acetaminophen-induced liver damage in patients. |
| first_indexed | 2024-12-10T21:59:29Z |
| format | Article |
| id | doaj.art-9b2214992c324ec7aaa914d2b57c3782 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-10T21:59:29Z |
| publishDate | 2016-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-9b2214992c324ec7aaa914d2b57c37822022-12-22T01:31:57ZengF1000 Research LtdF1000Research2046-14022016-07-01510.12688/f1000research.8609.19263From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective [version 1; referees: 2 approved]Swetha Rudraiah0José E. Manautou1Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT, USAToxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT, USAA variety of rodent models of hepatoprotection have been developed in which tolerance to acetaminophen-induced hepatotoxicity occurs. Autoprotection/heteroprotection is a phenomenon where prior exposure to a mildly toxic dose of toxicant confers protection against a subsequently administered higher dose of the same toxicant (as in the case of autoprotection) or to a different toxicant (referred to as heteroprotection). Multiple mechanisms regulate this adaptive response, including hepatocellular proliferation, proteostasis, enhanced expression of cytoprotective genes, and altered tissue immune response. In this review, we will discuss recent findings that highlight the complexity of these adaptive mechanisms and we also outline the usefulness of these findings to devise therapeutic and/or diagnostic tools for acetaminophen-induced liver damage in patients.http://f1000research.com/articles/5-1698/v1Control of Gene ExpressionGastrointestinal PhysiologyLiver Biology & PathobiologyLiver Failure & Liver DiseaseToxicology |
| spellingShingle | Swetha Rudraiah José E. Manautou From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective [version 1; referees: 2 approved] F1000Research Control of Gene Expression Gastrointestinal Physiology Liver Biology & Pathobiology Liver Failure & Liver Disease Toxicology |
| title | From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective [version 1; referees: 2 approved] |
| title_full | From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective [version 1; referees: 2 approved] |
| title_fullStr | From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective [version 1; referees: 2 approved] |
| title_full_unstemmed | From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective [version 1; referees: 2 approved] |
| title_short | From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspective [version 1; referees: 2 approved] |
| title_sort | from hepatoprotection models to new therapeutic modalities for treating liver diseases a personal perspective version 1 referees 2 approved |
| topic | Control of Gene Expression Gastrointestinal Physiology Liver Biology & Pathobiology Liver Failure & Liver Disease Toxicology |
| url | http://f1000research.com/articles/5-1698/v1 |
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