Review of Hepatitis E Virus in Rats: Evident Risk of Species <i>Orthohepevirus C</i> to Human Zoonotic Infection and Disease
Hepatitis E virus (HEV) (family <i>Hepeviridae</i>) is one of the most common human pathogens, causing acute hepatitis and an increasingly recognized etiological agent in chronic hepatitis and extrahepatic manifestations. Recent studies reported that not only are the classical members of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/10/1148 |
| _version_ | 1827704628889780224 |
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| author | Gábor Reuter Ákos Boros Péter Pankovics |
| author_facet | Gábor Reuter Ákos Boros Péter Pankovics |
| author_sort | Gábor Reuter |
| collection | DOAJ |
| description | Hepatitis E virus (HEV) (family <i>Hepeviridae</i>) is one of the most common human pathogens, causing acute hepatitis and an increasingly recognized etiological agent in chronic hepatitis and extrahepatic manifestations. Recent studies reported that not only are the classical members of the species <i>Orthohepevirus A</i> (HEV-A) pathogenic to humans but a genetically highly divergent rat origin hepevirus (HEV-C1) in species <i>Orthohepevirus C</i> (HEV-C) is also able to cause zoonotic infection and symptomatic disease (hepatitis) in humans. This review summarizes the current knowledge of hepeviruses in rodents with special focus of rat origin HEV-C1. Cross-species transmission and genetic diversity of HEV-C1 and confirmation of HEV-C1 infections and symptomatic disease in humans re-opened the long-lasting and full of surprises story of HEV in human. This novel knowledge has a consequence to the epidemiology, clinical aspects, laboratory diagnosis, and prevention of HEV infection in humans. |
| first_indexed | 2024-03-10T15:45:57Z |
| format | Article |
| id | doaj.art-9b221ec75c1b47efabd37d3005359475 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T15:45:57Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-9b221ec75c1b47efabd37d30053594752023-11-20T16:30:45ZengMDPI AGViruses1999-49152020-10-011210114810.3390/v12101148Review of Hepatitis E Virus in Rats: Evident Risk of Species <i>Orthohepevirus C</i> to Human Zoonotic Infection and DiseaseGábor Reuter0Ákos Boros1Péter Pankovics2Department of Medical Microbiology and Immunology, Medical School, University of Pécs, H-7624 Pécs, HungaryDepartment of Medical Microbiology and Immunology, Medical School, University of Pécs, H-7624 Pécs, HungaryDepartment of Medical Microbiology and Immunology, Medical School, University of Pécs, H-7624 Pécs, HungaryHepatitis E virus (HEV) (family <i>Hepeviridae</i>) is one of the most common human pathogens, causing acute hepatitis and an increasingly recognized etiological agent in chronic hepatitis and extrahepatic manifestations. Recent studies reported that not only are the classical members of the species <i>Orthohepevirus A</i> (HEV-A) pathogenic to humans but a genetically highly divergent rat origin hepevirus (HEV-C1) in species <i>Orthohepevirus C</i> (HEV-C) is also able to cause zoonotic infection and symptomatic disease (hepatitis) in humans. This review summarizes the current knowledge of hepeviruses in rodents with special focus of rat origin HEV-C1. Cross-species transmission and genetic diversity of HEV-C1 and confirmation of HEV-C1 infections and symptomatic disease in humans re-opened the long-lasting and full of surprises story of HEV in human. This novel knowledge has a consequence to the epidemiology, clinical aspects, laboratory diagnosis, and prevention of HEV infection in humans.https://www.mdpi.com/1999-4915/12/10/1148hepatitis E virushepevirusorthohepevirusrodentratzoonosis |
| spellingShingle | Gábor Reuter Ákos Boros Péter Pankovics Review of Hepatitis E Virus in Rats: Evident Risk of Species <i>Orthohepevirus C</i> to Human Zoonotic Infection and Disease Viruses hepatitis E virus hepevirus orthohepevirus rodent rat zoonosis |
| title | Review of Hepatitis E Virus in Rats: Evident Risk of Species <i>Orthohepevirus C</i> to Human Zoonotic Infection and Disease |
| title_full | Review of Hepatitis E Virus in Rats: Evident Risk of Species <i>Orthohepevirus C</i> to Human Zoonotic Infection and Disease |
| title_fullStr | Review of Hepatitis E Virus in Rats: Evident Risk of Species <i>Orthohepevirus C</i> to Human Zoonotic Infection and Disease |
| title_full_unstemmed | Review of Hepatitis E Virus in Rats: Evident Risk of Species <i>Orthohepevirus C</i> to Human Zoonotic Infection and Disease |
| title_short | Review of Hepatitis E Virus in Rats: Evident Risk of Species <i>Orthohepevirus C</i> to Human Zoonotic Infection and Disease |
| title_sort | review of hepatitis e virus in rats evident risk of species i orthohepevirus c i to human zoonotic infection and disease |
| topic | hepatitis E virus hepevirus orthohepevirus rodent rat zoonosis |
| url | https://www.mdpi.com/1999-4915/12/10/1148 |
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