Advanced lung organoids for respiratory system and pulmonary disease modeling
Amidst the recent coronavirus disease 2019 (COVID-19) pandemic, respiratory system research has made remarkable progress, particularly focusing on infectious diseases. Lung organoid, a miniaturized structure recapitulating lung tissue, has gained global attention because of its advantages over other...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-02-01
|
| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/20417314241232502 |
| _version_ | 1797296620911460352 |
|---|---|
| author | Hyebin Joo Sungjin Min Seung-Woo Cho |
| author_facet | Hyebin Joo Sungjin Min Seung-Woo Cho |
| author_sort | Hyebin Joo |
| collection | DOAJ |
| description | Amidst the recent coronavirus disease 2019 (COVID-19) pandemic, respiratory system research has made remarkable progress, particularly focusing on infectious diseases. Lung organoid, a miniaturized structure recapitulating lung tissue, has gained global attention because of its advantages over other conventional models such as two-dimensional (2D) cell models and animal models. Nevertheless, lung organoids still face limitations concerning heterogeneity, complexity, and maturity compared to the native lung tissue. To address these limitations, researchers have employed co-culture methods with various cell types including endothelial cells, mesenchymal cells, and immune cells, and incorporated bioengineering platforms such as air-liquid interfaces, microfluidic chips, and functional hydrogels. These advancements have facilitated applications of lung organoids to studies of pulmonary diseases, providing insights into disease mechanisms and potential treatments. This review introduces recent progress in the production methods of lung organoids, strategies for improving maturity, functionality, and complexity of organoids, and their application in disease modeling, including respiratory infection and pulmonary fibrosis. |
| first_indexed | 2024-03-07T22:07:25Z |
| format | Article |
| id | doaj.art-9b22ff5f41d545a18a43f3f3237afcb3 |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-03-07T22:07:25Z |
| publishDate | 2024-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-9b22ff5f41d545a18a43f3f3237afcb32024-02-23T19:04:03ZengSAGE PublishingJournal of Tissue Engineering2041-73142024-02-011510.1177/20417314241232502Advanced lung organoids for respiratory system and pulmonary disease modelingHyebin Joo0Sungjin Min1Seung-Woo Cho2Department of Biotechnology, Yonsei University, Seoul, Republic of KoreaDepartment of Biotechnology, Yonsei University, Seoul, Republic of KoreaCenter for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of KoreaAmidst the recent coronavirus disease 2019 (COVID-19) pandemic, respiratory system research has made remarkable progress, particularly focusing on infectious diseases. Lung organoid, a miniaturized structure recapitulating lung tissue, has gained global attention because of its advantages over other conventional models such as two-dimensional (2D) cell models and animal models. Nevertheless, lung organoids still face limitations concerning heterogeneity, complexity, and maturity compared to the native lung tissue. To address these limitations, researchers have employed co-culture methods with various cell types including endothelial cells, mesenchymal cells, and immune cells, and incorporated bioengineering platforms such as air-liquid interfaces, microfluidic chips, and functional hydrogels. These advancements have facilitated applications of lung organoids to studies of pulmonary diseases, providing insights into disease mechanisms and potential treatments. This review introduces recent progress in the production methods of lung organoids, strategies for improving maturity, functionality, and complexity of organoids, and their application in disease modeling, including respiratory infection and pulmonary fibrosis.https://doi.org/10.1177/20417314241232502 |
| spellingShingle | Hyebin Joo Sungjin Min Seung-Woo Cho Advanced lung organoids for respiratory system and pulmonary disease modeling Journal of Tissue Engineering |
| title | Advanced lung organoids for respiratory system and pulmonary disease modeling |
| title_full | Advanced lung organoids for respiratory system and pulmonary disease modeling |
| title_fullStr | Advanced lung organoids for respiratory system and pulmonary disease modeling |
| title_full_unstemmed | Advanced lung organoids for respiratory system and pulmonary disease modeling |
| title_short | Advanced lung organoids for respiratory system and pulmonary disease modeling |
| title_sort | advanced lung organoids for respiratory system and pulmonary disease modeling |
| url | https://doi.org/10.1177/20417314241232502 |
| work_keys_str_mv | AT hyebinjoo advancedlungorganoidsforrespiratorysystemandpulmonarydiseasemodeling AT sungjinmin advancedlungorganoidsforrespiratorysystemandpulmonarydiseasemodeling AT seungwoocho advancedlungorganoidsforrespiratorysystemandpulmonarydiseasemodeling |