Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis
Background: To assess effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis (RA). Materials and Methods: An open-labeled randomized trial was conducted comparing 60,000 IU 1,25 dihydroxy vitamin D3 + calcium (1000 mg/day) combination [Group A] versus calciu...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=2;spage=517;epage=522;aulast=Mukherjee |
| _version_ | 1819241743943467008 |
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| author | Dibyendu Mukherjee Sandeep Lahiry Sayanta Thakur Dwaipayan Sarathi Chakraborty |
| author_facet | Dibyendu Mukherjee Sandeep Lahiry Sayanta Thakur Dwaipayan Sarathi Chakraborty |
| author_sort | Dibyendu Mukherjee |
| collection | DOAJ |
| description | Background: To assess effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis (RA). Materials and Methods: An open-labeled randomized trial was conducted comparing 60,000 IU 1,25 dihydroxy vitamin D3 + calcium (1000 mg/day) combination [Group A] versus calcium (1000 mg/day) only [Group B], as supplement to existing treatment regimen in early RA. Primary outcome included (i) minimum time required for onset of pain relief (Tm) assessed through patients' visual analog scale (VAS); (ii) % change in VAS score from onset of pain relief to end of 8 weeks. Secondary outcome included change in disease activity score (DAS-28). Results: At the end of 8-weeks, Group A reported 50% higher median pain relief scores (80% vs. 30%; P < 0.001) and DAS-28 scores (2.9 ± 0.6 vs. 3.1 ± 0.4; P = 0.012) compared to Group B; however, Tm remained comparable (19 ± 2 vs. 20 ± 2 days; P = 0.419). Occurrence of hypovitaminosis-D was lower (23.3%) compared to Indian prevalence rates and was a risk factor for developing active disease (Odds Ratio (OR) = 7.52 [95% Confidence Interval (CI) 2.67–21.16], P < 0.0001). Vitamin D deficiency was significantly (P < 0.001) more common in female gender, active disease, and shorter mean disease duration. Vitamin D levels were inversely correlated to disease activity as assessed by DAS-28 (r = –0.604; P < 0.001). Conclusions: Vitamin-D deficiency is a risk factor for developing active disease in RA. Weekly supplementation of 60,000 IU of 1,25 dihydroxy vitamin D3 in early RA results in greater pain relief. The number needed to treat for this additional pain relief was 2. Identifier: CTRI/2018/01/011532 (www.ctri.nic.in). |
| first_indexed | 2024-12-23T14:28:46Z |
| format | Article |
| id | doaj.art-9b234169e57f4f22bd6fd660a855f043 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-23T14:28:46Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-9b234169e57f4f22bd6fd660a855f0432022-12-21T17:43:35ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632019-01-018251752210.4103/jfmpc.jfmpc_446_18Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritisDibyendu MukherjeeSandeep LahirySayanta ThakurDwaipayan Sarathi ChakrabortyBackground: To assess effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis (RA). Materials and Methods: An open-labeled randomized trial was conducted comparing 60,000 IU 1,25 dihydroxy vitamin D3 + calcium (1000 mg/day) combination [Group A] versus calcium (1000 mg/day) only [Group B], as supplement to existing treatment regimen in early RA. Primary outcome included (i) minimum time required for onset of pain relief (Tm) assessed through patients' visual analog scale (VAS); (ii) % change in VAS score from onset of pain relief to end of 8 weeks. Secondary outcome included change in disease activity score (DAS-28). Results: At the end of 8-weeks, Group A reported 50% higher median pain relief scores (80% vs. 30%; P < 0.001) and DAS-28 scores (2.9 ± 0.6 vs. 3.1 ± 0.4; P = 0.012) compared to Group B; however, Tm remained comparable (19 ± 2 vs. 20 ± 2 days; P = 0.419). Occurrence of hypovitaminosis-D was lower (23.3%) compared to Indian prevalence rates and was a risk factor for developing active disease (Odds Ratio (OR) = 7.52 [95% Confidence Interval (CI) 2.67–21.16], P < 0.0001). Vitamin D deficiency was significantly (P < 0.001) more common in female gender, active disease, and shorter mean disease duration. Vitamin D levels were inversely correlated to disease activity as assessed by DAS-28 (r = –0.604; P < 0.001). Conclusions: Vitamin-D deficiency is a risk factor for developing active disease in RA. Weekly supplementation of 60,000 IU of 1,25 dihydroxy vitamin D3 in early RA results in greater pain relief. The number needed to treat for this additional pain relief was 2. Identifier: CTRI/2018/01/011532 (www.ctri.nic.in).http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=2;spage=517;epage=522;aulast=Mukherjee125 dihydroxy vitamin D3early rheumatoid arthritispain reliefvisual analogue scale |
| spellingShingle | Dibyendu Mukherjee Sandeep Lahiry Sayanta Thakur Dwaipayan Sarathi Chakraborty Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis Journal of Family Medicine and Primary Care 1 25 dihydroxy vitamin D3 early rheumatoid arthritis pain relief visual analogue scale |
| title | Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis |
| title_full | Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis |
| title_fullStr | Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis |
| title_full_unstemmed | Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis |
| title_short | Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis |
| title_sort | effect of 1 25 dihydroxy vitamin d3 supplementation on pain relief in early rheumatoid arthritis |
| topic | 1 25 dihydroxy vitamin D3 early rheumatoid arthritis pain relief visual analogue scale |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=2;spage=517;epage=522;aulast=Mukherjee |
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