Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance
The ability of T cells to identify foreign antigens and mount an efficient immune response while limiting activation upon recognition of self and self-associated peptides is critical. Multiple tolerance mechanisms work in concert to prevent the generation and activation of self-reactive T cells. T c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1530 |
| _version_ | 1797529777867849728 |
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| author | Sébastien This Stefanie F. Valbon Marie-Ève Lebel Heather J. Melichar |
| author_facet | Sébastien This Stefanie F. Valbon Marie-Ève Lebel Heather J. Melichar |
| author_sort | Sébastien This |
| collection | DOAJ |
| description | The ability of T cells to identify foreign antigens and mount an efficient immune response while limiting activation upon recognition of self and self-associated peptides is critical. Multiple tolerance mechanisms work in concert to prevent the generation and activation of self-reactive T cells. T cell tolerance is tightly regulated, as defects in these processes can lead to devastating disease; a wide variety of autoimmune diseases and, more recently, adverse immune-related events associated with checkpoint blockade immunotherapy have been linked to a breakdown in T cell tolerance. The quantity and quality of antigen receptor signaling depend on a variety of parameters that include T cell receptor affinity and avidity for peptide. Autoreactive T cell fate choices (e.g., deletion, anergy, regulatory T cell development) are highly dependent on the strength of T cell receptor interactions with self-peptide. However, less is known about how differences in the strength of T cell receptor signaling during differentiation influences the ‘function’ and persistence of anergic and regulatory T cell populations. Here, we review the literature on this subject and discuss the clinical implications of how T cell receptor signal strength influences the ‘quality’ of anergic and regulatory T cell populations. |
| first_indexed | 2024-03-10T10:19:42Z |
| format | Article |
| id | doaj.art-9b234db037dd41e080b079fef4298041 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:19:42Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9b234db037dd41e080b079fef42980412023-11-22T00:33:52ZengMDPI AGCells2073-44092021-06-01106153010.3390/cells10061530Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell ToleranceSébastien This0Stefanie F. Valbon1Marie-Ève Lebel2Heather J. Melichar3Centre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, CanadaCentre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, CanadaCentre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, CanadaCentre de Recherche de l’Hôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, CanadaThe ability of T cells to identify foreign antigens and mount an efficient immune response while limiting activation upon recognition of self and self-associated peptides is critical. Multiple tolerance mechanisms work in concert to prevent the generation and activation of self-reactive T cells. T cell tolerance is tightly regulated, as defects in these processes can lead to devastating disease; a wide variety of autoimmune diseases and, more recently, adverse immune-related events associated with checkpoint blockade immunotherapy have been linked to a breakdown in T cell tolerance. The quantity and quality of antigen receptor signaling depend on a variety of parameters that include T cell receptor affinity and avidity for peptide. Autoreactive T cell fate choices (e.g., deletion, anergy, regulatory T cell development) are highly dependent on the strength of T cell receptor interactions with self-peptide. However, less is known about how differences in the strength of T cell receptor signaling during differentiation influences the ‘function’ and persistence of anergic and regulatory T cell populations. Here, we review the literature on this subject and discuss the clinical implications of how T cell receptor signal strength influences the ‘quality’ of anergic and regulatory T cell populations.https://www.mdpi.com/2073-4409/10/6/1530T cellstoleranceT cell receptor signalingaffinityavidityanergy |
| spellingShingle | Sébastien This Stefanie F. Valbon Marie-Ève Lebel Heather J. Melichar Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance Cells T cells tolerance T cell receptor signaling affinity avidity anergy |
| title | Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance |
| title_full | Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance |
| title_fullStr | Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance |
| title_full_unstemmed | Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance |
| title_short | Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance |
| title_sort | strength and numbers the role of affinity and avidity in the quality of t cell tolerance |
| topic | T cells tolerance T cell receptor signaling affinity avidity anergy |
| url | https://www.mdpi.com/2073-4409/10/6/1530 |
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