Dehydroepiandrosterone Sulfate and Arterial Hypertension
Dehydroepiandrosterone sulfate (DHEAS) is a steroid molecule whose function and mechanism of action in the human body are still inadequately researched. A potential protective function for the cardiovascular system can be explained by activation of nitric oxide production, impact on endothelial and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Osijek
2022-04-01
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| Series: | Southeastern European Medical Journal |
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| Online Access: | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/228/129 |
| _version_ | 1818193553821532160 |
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| author | Juraj Jug Martina Matovinović |
| author_facet | Juraj Jug Martina Matovinović |
| author_sort | Juraj Jug |
| collection | DOAJ |
| description | Dehydroepiandrosterone sulfate (DHEAS) is a steroid molecule whose function and mechanism of action in the human body are still inadequately researched. A potential protective function for the cardiovascular system can be explained by activation of nitric oxide production, impact on endothelial and mitochondrial function, and inhibition of proinflammatory cytokine production (IL-6 and TNF-α). Some research shows the beneficial effects of DHEA/DHEAS on many bodily functions, especially in the cardiovascular and the neurological systems. However, we need to be careful with interpretation of the results because of different criteria used for defining arterial hypertension, the race that was observed, and reproductive status of women, as these factors can change the conclusion. Due to a lack of evidence, DHEAS supplementation is still not recommended. We need multicentric prospective and randomized studies on DHEAS to examine its potential impact on blood pressure regulation and cardiovascular risk. |
| first_indexed | 2024-12-12T00:48:14Z |
| format | Article |
| id | doaj.art-9b23896ec04042e5bbac6ca153258aa2 |
| institution | Directory Open Access Journal |
| issn | 2459-9484 |
| language | English |
| last_indexed | 2024-12-12T00:48:14Z |
| publishDate | 2022-04-01 |
| publisher | Faculty of Medicine Osijek |
| record_format | Article |
| series | Southeastern European Medical Journal |
| spelling | doaj.art-9b23896ec04042e5bbac6ca153258aa22022-12-22T00:44:05ZengFaculty of Medicine OsijekSoutheastern European Medical Journal2459-94842022-04-0161687310.26332/seemedj.v6i1.228Dehydroepiandrosterone Sulfate and Arterial HypertensionJuraj Jug0https://orcid.org/0000-0002-3189-1518Martina Matovinović1https://orcid.org/0000-0002-6325-7394Health center Zagreb West, Zagreb, CroatiaClinical hospital center Zagreb, CroatiaDehydroepiandrosterone sulfate (DHEAS) is a steroid molecule whose function and mechanism of action in the human body are still inadequately researched. A potential protective function for the cardiovascular system can be explained by activation of nitric oxide production, impact on endothelial and mitochondrial function, and inhibition of proinflammatory cytokine production (IL-6 and TNF-α). Some research shows the beneficial effects of DHEA/DHEAS on many bodily functions, especially in the cardiovascular and the neurological systems. However, we need to be careful with interpretation of the results because of different criteria used for defining arterial hypertension, the race that was observed, and reproductive status of women, as these factors can change the conclusion. Due to a lack of evidence, DHEAS supplementation is still not recommended. We need multicentric prospective and randomized studies on DHEAS to examine its potential impact on blood pressure regulation and cardiovascular risk.http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/228/129arterial hypertensiondehydroepiandrosterone sulfatemenopauseneuroprotection |
| spellingShingle | Juraj Jug Martina Matovinović Dehydroepiandrosterone Sulfate and Arterial Hypertension Southeastern European Medical Journal arterial hypertension dehydroepiandrosterone sulfate menopause neuroprotection |
| title | Dehydroepiandrosterone Sulfate and Arterial Hypertension |
| title_full | Dehydroepiandrosterone Sulfate and Arterial Hypertension |
| title_fullStr | Dehydroepiandrosterone Sulfate and Arterial Hypertension |
| title_full_unstemmed | Dehydroepiandrosterone Sulfate and Arterial Hypertension |
| title_short | Dehydroepiandrosterone Sulfate and Arterial Hypertension |
| title_sort | dehydroepiandrosterone sulfate and arterial hypertension |
| topic | arterial hypertension dehydroepiandrosterone sulfate menopause neuroprotection |
| url | http://seemedj.mefos.unios.hr/index.php/seemedj/article/view/228/129 |
| work_keys_str_mv | AT jurajjug dehydroepiandrosteronesulfateandarterialhypertension AT martinamatovinovic dehydroepiandrosteronesulfateandarterialhypertension |