Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Abstract Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and neurodegeneration-specific microglial profiles with unclear significance in Alzheimer’s disease (AD). An understanding of heterogeneity within DAM and their key regulators may guide pre-clinical experimen...

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Bibliographic Details
Main Authors: Srikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Priyadharshini Rathakrishnan, Hailian Xiao, Tianwen Gao, Duc M. Duong, Michael W. Pennington, James J. Lah, Nicholas T. Seyfried, Allan I. Levey
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Neurodegeneration
Subjects:
Microglia
Macrophage
Alzheimer’s disease
Network analysis
Kv1.3
Potassium channel
Online Access:http://link.springer.com/article/10.1186/s13024-018-0254-8

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