Injurious Effect of Cisplatin on the Function of Hypothalamus-pituitary-adrenal/gonadal Axis in Mice and the Intervention Effect of Dehydroepiandrosterone

Injurious Effect of Cisplatin on the Function of Hypothalamus-pituitary-adrenal/gonadal Axis in Mice and the Intervention Effect of Dehydroepiandrosterone

Objective To study the pathway of cis-dichlorodiamineplatinum (DDP) inhibiting the synthesis of steroid hormones in mice, and to observe the intervention effect of dehydroepiandrosterone (DHEA). Methods Sixty adult ICR mice were randomly divided into three groups: control group, DDP modeling group,...

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Bibliographic Details
Main Authors: PAN Zhiqiang, NONG Zixin, XIE Haina, PENG Peike
Format: Article
Language:zho
Published: Editorial Office of Laboratory Animal and Comparative Medicine 2023-06-01
Series:Shiyan dongwu yu bijiao yixue
Subjects:
cisplatin
dehydroepiandrosterone
testis
ovary
steroid hormone
mice
Online Access:https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2022.182

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