Aptamers as a sensitive tool to detect subtle modifications in therapeutic proteins.

Aptamers as a sensitive tool to detect subtle modifications in therapeutic proteins.

Therapeutic proteins are derived from complex expression/production systems, which can result in minor conformational changes due to preferential codon usage in different organisms, post-translational modifications, etc. Subtle conformational differences are often undetectable by bioanalytical metho...

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Bibliographic Details
Main Authors: Ran Zichel, Wanida Chearwae, Gouri Shankar Pandey, Basil Golding, Zuben E Sauna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3288073?pdf=render

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