TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis

TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis

Wnt signaling through the Frizzled (FZD) family of serpentine receptors is essential for embryogenesis and homeostasis, and stringent control of the FZD protein level is critical for stem cell regulation. Through CRISPR/Cas9 genome-wide screening in human cells, we identified TMEM79/MATTRIN, an orph...

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Bibliographic Details
Main Authors: Maorong Chen, Nathalia Amado, Jieqiong Tan, Alice Reis, Mengxu Ge, Jose Garcia Abreu, Xi He
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
tmem79/mattrin
frizzled
WNT
USP8
neural induction
anterior-posterior (ap) patterning
Online Access:https://elifesciences.org/articles/56793

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