Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India
AbstractBackground The prevalence of obesity and dyslipidaemia was observed to be increased among the tribal populations, due to globalization.Materials and methods In the present study, data on demographic, somatometric and blood samples were collected from 613 participants of both sex, age 18–60 y...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1969034 |
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| author | Somorjit Singh Ningombam Masan Kambo Newmei Varhlun Chhungi Prakash Ranjan Mondal Naorem Kiranmala Devi Kallur Nava Saraswathy |
| author_facet | Somorjit Singh Ningombam Masan Kambo Newmei Varhlun Chhungi Prakash Ranjan Mondal Naorem Kiranmala Devi Kallur Nava Saraswathy |
| author_sort | Somorjit Singh Ningombam |
| collection | DOAJ |
| description | AbstractBackground The prevalence of obesity and dyslipidaemia was observed to be increased among the tribal populations, due to globalization.Materials and methods In the present study, data on demographic, somatometric and blood samples were collected from 613 participants of both sex, age 18–60 years, further lipid profiling and genotyping was executed. Multifactor dimensionality reduction (MDR) software was used for gene–gene interactions analysis.Results Significantly differences were observed with respect to the general characteristic and selected gene polymorphisms in both the tribes. Among the Liangmai tribe, MC4R gene was found to pose significant decreased risk for waist–height ratio (WHtR) (OR = 0.56; 95% confidence interval (CI)= 0.32–0.99; p value = .04) and HDL (OR = 0.58; 95% CI = 0.36–0.92; p value = .02). Similar trends of significant decreased risk (OR = 0.39; 95% CI = 0.20–0.76; p value=.006) for BMI were observed among the Mizo tribe. The gene–gene interaction revealed the combined model of FTO+MC4R genes shows an increased risk for BMI in both the tribes. The independent significant increased risk posed by FTO gene was moderated by interaction with MC4R gene.Conclusions The observed differences can possibly attribute to both their respective ancestries resulting in different gene pools and the physical environment. The results of the study highlight the importance of gene–gene and gene–environment interactions in adverse phenotype groups.KEY MESSAGEAmong the tribal population, the prevalence of obesity and dyslipidaemia has been increased.Differential distribution and associations of selected markers hint towards differential genetic architecture in these populations.MC4R rs17782313 polymorphism was found to show a significantly decreased risk for WHtR and low HDL among the Liangmai tribe and BMI among the Mizo tribe.Significant increased risk posed by FTO rs9939609 gene polymorphism was moderated by the interaction with MC4R rs17782313. |
| first_indexed | 2024-03-08T21:58:13Z |
| format | Article |
| id | doaj.art-9b2b8979a7114f19b58cd92fda0a68bb |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:58:13Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-9b2b8979a7114f19b58cd92fda0a68bb2023-12-19T16:46:27ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-015311439144710.1080/07853890.2021.1969034Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, IndiaSomorjit Singh Ningombam0Masan Kambo Newmei1Varhlun Chhungi2Prakash Ranjan Mondal3Naorem Kiranmala Devi4Kallur Nava Saraswathy5Laboratory Oncology Unit, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, IndiaNational Family Health Survey-5, ICMR-National Institute of Malaria Research, New Delhi, IndiaDepartment of Anthropology, Laboratory of Biological and Molecular Anthropology, University of Delhi, New Delhi, IndiaDepartment of Anthropology, Laboratory of Biological and Molecular Anthropology, University of Delhi, New Delhi, IndiaDepartment of Anthropology, Laboratory of Biological and Molecular Anthropology, University of Delhi, New Delhi, IndiaAbstractBackground The prevalence of obesity and dyslipidaemia was observed to be increased among the tribal populations, due to globalization.Materials and methods In the present study, data on demographic, somatometric and blood samples were collected from 613 participants of both sex, age 18–60 years, further lipid profiling and genotyping was executed. Multifactor dimensionality reduction (MDR) software was used for gene–gene interactions analysis.Results Significantly differences were observed with respect to the general characteristic and selected gene polymorphisms in both the tribes. Among the Liangmai tribe, MC4R gene was found to pose significant decreased risk for waist–height ratio (WHtR) (OR = 0.56; 95% confidence interval (CI)= 0.32–0.99; p value = .04) and HDL (OR = 0.58; 95% CI = 0.36–0.92; p value = .02). Similar trends of significant decreased risk (OR = 0.39; 95% CI = 0.20–0.76; p value=.006) for BMI were observed among the Mizo tribe. The gene–gene interaction revealed the combined model of FTO+MC4R genes shows an increased risk for BMI in both the tribes. The independent significant increased risk posed by FTO gene was moderated by interaction with MC4R gene.Conclusions The observed differences can possibly attribute to both their respective ancestries resulting in different gene pools and the physical environment. The results of the study highlight the importance of gene–gene and gene–environment interactions in adverse phenotype groups.KEY MESSAGEAmong the tribal population, the prevalence of obesity and dyslipidaemia has been increased.Differential distribution and associations of selected markers hint towards differential genetic architecture in these populations.MC4R rs17782313 polymorphism was found to show a significantly decreased risk for WHtR and low HDL among the Liangmai tribe and BMI among the Mizo tribe.Significant increased risk posed by FTO rs9939609 gene polymorphism was moderated by the interaction with MC4R rs17782313.https://www.tandfonline.com/doi/10.1080/07853890.2021.1969034Cardiovascular diseasesgenetic association variationtribesNorth-East India |
| spellingShingle | Somorjit Singh Ningombam Masan Kambo Newmei Varhlun Chhungi Prakash Ranjan Mondal Naorem Kiranmala Devi Kallur Nava Saraswathy Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India Annals of Medicine Cardiovascular diseases genetic association variation tribes North-East India |
| title | Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India |
| title_full | Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India |
| title_fullStr | Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India |
| title_full_unstemmed | Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India |
| title_short | Obesity, dyslipidaemia and candidate gene polymorphisms: a cross-sectional study among the Liangmai and Mizo tribes of Manipur, India |
| title_sort | obesity dyslipidaemia and candidate gene polymorphisms a cross sectional study among the liangmai and mizo tribes of manipur india |
| topic | Cardiovascular diseases genetic association variation tribes North-East India |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1969034 |
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