Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus
ABSTRACT Objective: To evaluate the prevalence of osteosarcopenia and the association of osteosarcopenia with trabecular bone score (TBS) in a group of patients with type 2 diabetes mellitus(T2DMG) compared with a paired control group (CG). Materials and methods: Cross-sectional study with men and...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2021-11-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000600801&tlng=en |
| _version_ | 1818972668455550976 |
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| author | Luciana Muniz Pechmann Ricardo R. Petterle Carolina A. Moreira Victoria Z. C. Borba |
| author_facet | Luciana Muniz Pechmann Ricardo R. Petterle Carolina A. Moreira Victoria Z. C. Borba |
| author_sort | Luciana Muniz Pechmann |
| collection | DOAJ |
| description | ABSTRACT Objective: To evaluate the prevalence of osteosarcopenia and the association of osteosarcopenia with trabecular bone score (TBS) in a group of patients with type 2 diabetes mellitus(T2DMG) compared with a paired control group (CG). Materials and methods: Cross-sectional study with men and women ≥ 50 years recruited by convenience. Patients in both groups answered questionnaires and underwent evaluation of bone mineral density (BMD), handgrip strength (HGS), and TBS. The T2DMG also underwent a gait speed (GS) test. Sarcopenia was defined as low lean mass plus low HGS or GS according to the Foundation for the National Institute of Health Sarcopenia Project, and osteosarcopenia was deemed present when sarcopenia was associated with osteopenia, osteoporosis, or low-energy trauma fractures. Results: The T2DMG (n = 177) and CG (n = 146) had, respectively, mean ages of 65.1 ± 8.2 years and 68.8 ± 11.0 years and 114 (64.4%) and 80 (54.7%) women. T2DMG versus the CG had higher rates of osteosarcopenia (11.9% versus 2.14%, respectively, p = 0.010), sarcopenia (12.9% versus 5.4%, respectively, p < 0.030), and fractures (29.9% versus 18.5%, respectively, p = 0.019), and lower HGS values (24.4 ± 10.3 kg versus 30.9 ± 9.15 kg, respectively, p < 0.001), but comparable BMD values. Mean TBS values were 1.272 ± 0.11 and 1.320 ± 0.12, respectively (p = 0.001). On multivariate analysis, age, greater waist circumference, fractures, and osteoporosis increased the risk of degraded TBS. Osteosarcopenia was associated with diabetes complications (p = 0.03), calcium and vitamin D supplementation (p = 0.01), and all components of osteosarcopenia diagnosis (p < 0.05). Conclusion: Compared with the CG, the T2DMG had a higher prevalence of osteosarcopenia, sarcopenia, and fractures and lower bone quality assessed by TBS. |
| first_indexed | 2024-12-20T15:11:56Z |
| format | Article |
| id | doaj.art-9b2bbc694eab46d39edbfb581f78a8a0 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-20T15:11:56Z |
| publishDate | 2021-11-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-9b2bbc694eab46d39edbfb581f78a8a02022-12-21T19:36:17ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922021-11-0165680181010.20945/2359-3997000000418Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitusLuciana Muniz Pechmannhttps://orcid.org/0000-0002-2965-5268Ricardo R. Petterlehttps://orcid.org/0000-0001-7735-1077Carolina A. Moreirahttps://orcid.org/0000-0002-9908-4907Victoria Z. C. Borbahttps://orcid.org/0000-0003-0555-0880ABSTRACT Objective: To evaluate the prevalence of osteosarcopenia and the association of osteosarcopenia with trabecular bone score (TBS) in a group of patients with type 2 diabetes mellitus(T2DMG) compared with a paired control group (CG). Materials and methods: Cross-sectional study with men and women ≥ 50 years recruited by convenience. Patients in both groups answered questionnaires and underwent evaluation of bone mineral density (BMD), handgrip strength (HGS), and TBS. The T2DMG also underwent a gait speed (GS) test. Sarcopenia was defined as low lean mass plus low HGS or GS according to the Foundation for the National Institute of Health Sarcopenia Project, and osteosarcopenia was deemed present when sarcopenia was associated with osteopenia, osteoporosis, or low-energy trauma fractures. Results: The T2DMG (n = 177) and CG (n = 146) had, respectively, mean ages of 65.1 ± 8.2 years and 68.8 ± 11.0 years and 114 (64.4%) and 80 (54.7%) women. T2DMG versus the CG had higher rates of osteosarcopenia (11.9% versus 2.14%, respectively, p = 0.010), sarcopenia (12.9% versus 5.4%, respectively, p < 0.030), and fractures (29.9% versus 18.5%, respectively, p = 0.019), and lower HGS values (24.4 ± 10.3 kg versus 30.9 ± 9.15 kg, respectively, p < 0.001), but comparable BMD values. Mean TBS values were 1.272 ± 0.11 and 1.320 ± 0.12, respectively (p = 0.001). On multivariate analysis, age, greater waist circumference, fractures, and osteoporosis increased the risk of degraded TBS. Osteosarcopenia was associated with diabetes complications (p = 0.03), calcium and vitamin D supplementation (p = 0.01), and all components of osteosarcopenia diagnosis (p < 0.05). Conclusion: Compared with the CG, the T2DMG had a higher prevalence of osteosarcopenia, sarcopenia, and fractures and lower bone quality assessed by TBS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000600801&tlng=enSarcopeniatype 2 diabetes mellitusmuscle weaknessfracturesosteoporosis |
| spellingShingle | Luciana Muniz Pechmann Ricardo R. Petterle Carolina A. Moreira Victoria Z. C. Borba Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus Archives of Endocrinology and Metabolism Sarcopenia type 2 diabetes mellitus muscle weakness fractures osteoporosis |
| title | Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus |
| title_full | Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus |
| title_fullStr | Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus |
| title_short | Osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus |
| title_sort | osteosarcopenia and trabecular bone score in patients with type 2 diabetes mellitus |
| topic | Sarcopenia type 2 diabetes mellitus muscle weakness fractures osteoporosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000600801&tlng=en |
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