Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing country
Abstract Background Pseudomonas infections are among the most common infections encountered in hospitalized patients, especially those with chronic illnesses or an immunocompromised state. Management of these infections has become challenging due to increased antibiotic resistance. Therefore, this s...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Antimicrobial Resistance and Infection Control |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13756-023-01355-4 |
| _version_ | 1797376784865427456 |
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| author | Sara Shbaita Safaa Abatli Mamoun W. Sweileh Banan M Aiesh Ali Sabateen Husam T. Salameh Adham AbuTaha Sa’ed H. Zyoud |
| author_facet | Sara Shbaita Safaa Abatli Mamoun W. Sweileh Banan M Aiesh Ali Sabateen Husam T. Salameh Adham AbuTaha Sa’ed H. Zyoud |
| author_sort | Sara Shbaita |
| collection | DOAJ |
| description | Abstract Background Pseudomonas infections are among the most common infections encountered in hospitalized patients, especially those with chronic illnesses or an immunocompromised state. Management of these infections has become challenging due to increased antibiotic resistance. Therefore, this study examines the antibiotic resistance profiles of Pseudomonas spp. and the associated factors among patients admitted to a large tertiary hospital in a developing country. Methods This retrospective observational chart review study assessed patients admitted to a large tertiary hospital in a developing country with a positive culture growth of Pseudomonas from anybody site. Antibiotic susceptibility of the isolated Pseudomonas and patient characteristics were studied from the start of 2021 to the end of 2022. The study ground consisted of 185 patients. Results The study included 185 patients with positive Pseudomonas isolates. Males constituted 54.6% of the sample, while 45.4% were females. The median age of the patients was 53 years. Patient comorbidities and risk factors for Pseudomonas infection and multidrug resistance were assessed. Antibiotic resistance to the Pseudomonas regimens showed the highest resistance to meropenem and ciprofloxacin (23.4%, similarly) among isolates of Pseudomonas aeruginosa. Multidrug resistance (MDR) was found in 108 (58.4%) isolates. The most commonly used antibiotic for treatment was piperacillin-tazobactam, accounting for 33.3% of cases, followed by aminoglycosides at 26.6%. Conclusions Pseudomonas aeruginosa isolates were resistant to meropenem and ciprofloxacin. Over half of the isolates were multidrug-resistant, which was worrying. Piperacillin-tazobactam and aminoglycosides were the most often utilized antibiotics, highlighting the significance of susceptibility testing. Implementing antimicrobial stewardship programs and infection control measures can help reduce drug resistance and improve outcomes in Pseudomonas infections. |
| first_indexed | 2024-03-08T19:43:36Z |
| format | Article |
| id | doaj.art-9b2c985e95874f059266ab11b7f76c84 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-03-08T19:43:36Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-9b2c985e95874f059266ab11b7f76c842023-12-24T12:29:34ZengBMCAntimicrobial Resistance and Infection Control2047-29942023-12-0112111210.1186/s13756-023-01355-4Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing countrySara Shbaita0Safaa Abatli1Mamoun W. Sweileh2Banan M Aiesh3Ali Sabateen4Husam T. Salameh5Adham AbuTaha6Sa’ed H. Zyoud7Department of Medicine, College of Medicine and Health Sciences, An-Najah National UniversityDepartment of Medicine, College of Medicine and Health Sciences, An-Najah National UniversityDepartment of Internal Medicine, An-Najah National University HospitalInfection Control Department, An-Najah National University HospitalInfection Control Department, An-Najah National University HospitalDepartment of Medicine, College of Medicine and Health Sciences, An-Najah National UniversityDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National UniversityDepartment of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National UniversityAbstract Background Pseudomonas infections are among the most common infections encountered in hospitalized patients, especially those with chronic illnesses or an immunocompromised state. Management of these infections has become challenging due to increased antibiotic resistance. Therefore, this study examines the antibiotic resistance profiles of Pseudomonas spp. and the associated factors among patients admitted to a large tertiary hospital in a developing country. Methods This retrospective observational chart review study assessed patients admitted to a large tertiary hospital in a developing country with a positive culture growth of Pseudomonas from anybody site. Antibiotic susceptibility of the isolated Pseudomonas and patient characteristics were studied from the start of 2021 to the end of 2022. The study ground consisted of 185 patients. Results The study included 185 patients with positive Pseudomonas isolates. Males constituted 54.6% of the sample, while 45.4% were females. The median age of the patients was 53 years. Patient comorbidities and risk factors for Pseudomonas infection and multidrug resistance were assessed. Antibiotic resistance to the Pseudomonas regimens showed the highest resistance to meropenem and ciprofloxacin (23.4%, similarly) among isolates of Pseudomonas aeruginosa. Multidrug resistance (MDR) was found in 108 (58.4%) isolates. The most commonly used antibiotic for treatment was piperacillin-tazobactam, accounting for 33.3% of cases, followed by aminoglycosides at 26.6%. Conclusions Pseudomonas aeruginosa isolates were resistant to meropenem and ciprofloxacin. Over half of the isolates were multidrug-resistant, which was worrying. Piperacillin-tazobactam and aminoglycosides were the most often utilized antibiotics, highlighting the significance of susceptibility testing. Implementing antimicrobial stewardship programs and infection control measures can help reduce drug resistance and improve outcomes in Pseudomonas infections.https://doi.org/10.1186/s13756-023-01355-4Pseudomonas aeruginosaMultidrug-resistant PseudomonasAntibiotic resistanceMDR |
| spellingShingle | Sara Shbaita Safaa Abatli Mamoun W. Sweileh Banan M Aiesh Ali Sabateen Husam T. Salameh Adham AbuTaha Sa’ed H. Zyoud Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing country Antimicrobial Resistance and Infection Control Pseudomonas aeruginosa Multidrug-resistant Pseudomonas Antibiotic resistance MDR |
| title | Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing country |
| title_full | Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing country |
| title_fullStr | Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing country |
| title_full_unstemmed | Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing country |
| title_short | Antibiotic resistance profiles and associated factors of Pseudomonas Infections among patients admitted to large tertiary care hospital from a developing country |
| title_sort | antibiotic resistance profiles and associated factors of pseudomonas infections among patients admitted to large tertiary care hospital from a developing country |
| topic | Pseudomonas aeruginosa Multidrug-resistant Pseudomonas Antibiotic resistance MDR |
| url | https://doi.org/10.1186/s13756-023-01355-4 |
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