Assessment of Opioid-Induced Immunomodulation in Experimental and Clinical Sepsis

CONTEXT:. Opioids remain a standard supportive therapy in patients admitted to the ICU with sepsis. However, as preclinical models indicate an association between opioid exposure and immunosuppression, the use of this class of drugs warrants investigation. The objective of this study was to investig...

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Bibliographic Details
Main Authors: Brittany D. Bissell, PharmD, PhD, FCCM, BCCCP, Jamie L. Sturgill, PhD, Maria E. C. Bruno, PhD, Erick D. Lewis, MS, Marlene E. Starr, PhD
Format: Article
Language:English
Published: Wolters Kluwer 2023-01-01
Series:Critical Care Explorations
Online Access:http://journals.lww.com/10.1097/CCE.0000000000000849