Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes Mellitus
Antioxidant status imbalance and inflammatory process are cooperative events involved in type 2 diabetes mellitus. This study aimed to investigate superoxide dismutase as a potential biomarkers of antioxidant imbalance, matrix-metaloprotinase-9, and interleukin -18 as biomarkers of inflammat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2017-07-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://www.bijps.uobaghdad.edu.iq/index.php/bijps/article/view/682 |
| _version_ | 1797317333403828224 |
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| author | Shatha R. Moustafa Shawn A. Omar |
| author_facet | Shatha R. Moustafa Shawn A. Omar |
| author_sort | Shatha R. Moustafa |
| collection | DOAJ |
| description |
Antioxidant status imbalance and inflammatory process are cooperative events involved in type 2 diabetes mellitus. This study aimed to investigate superoxide dismutase as a potential biomarkers of antioxidant imbalance, matrix-metaloprotinase-9, and interleukin -18 as biomarkers of inflammation in serum and to estimate the effects of other confounding factors gender, age and finally measuring the relation among the interested biomarkers.
This case - control study included 50 patients, and 45 of healthy subjects matched age –gender were also enrolled in this study as a control group. The focused parameters were measured using ELISA technique. There was significant reduction in the serum superoxide dismutase level and significant elevation in serum matrix- metaloptotinase-9 and interleukin -18 levels which have been associated with diabetes.
This finding may explain the role of the defect in antioxidants status leading to significant reduction in serum superoxide dismutase levels associated with increased inflammatory process leading to significant elevations of a matrix- metaloptotinase-9 and interleukin -18. These parameters added a diagnostic information and evaluated as potential tools for disease risk prediction.
Keywords: Type 2 diabetes mellitus, Superoxide dismutase, Matrix metaloptotinase-9 and Interleukin -18.
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| first_indexed | 2024-03-08T03:33:24Z |
| format | Article |
| id | doaj.art-9b2efb8b0c69446eac9c5857ac625f12 |
| institution | Directory Open Access Journal |
| issn | 1683-3597 2521-3512 |
| language | English |
| last_indexed | 2024-03-08T03:33:24Z |
| publishDate | 2017-07-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-9b2efb8b0c69446eac9c5857ac625f122024-02-10T10:58:01ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122017-07-0126110.31351/vol26iss1pp17-25Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes MellitusShatha R. MoustafaShawn A. Omar Antioxidant status imbalance and inflammatory process are cooperative events involved in type 2 diabetes mellitus. This study aimed to investigate superoxide dismutase as a potential biomarkers of antioxidant imbalance, matrix-metaloprotinase-9, and interleukin -18 as biomarkers of inflammation in serum and to estimate the effects of other confounding factors gender, age and finally measuring the relation among the interested biomarkers. This case - control study included 50 patients, and 45 of healthy subjects matched age –gender were also enrolled in this study as a control group. The focused parameters were measured using ELISA technique. There was significant reduction in the serum superoxide dismutase level and significant elevation in serum matrix- metaloptotinase-9 and interleukin -18 levels which have been associated with diabetes. This finding may explain the role of the defect in antioxidants status leading to significant reduction in serum superoxide dismutase levels associated with increased inflammatory process leading to significant elevations of a matrix- metaloptotinase-9 and interleukin -18. These parameters added a diagnostic information and evaluated as potential tools for disease risk prediction. Keywords: Type 2 diabetes mellitus, Superoxide dismutase, Matrix metaloptotinase-9 and Interleukin -18. https://www.bijps.uobaghdad.edu.iq/index.php/bijps/article/view/682Type 2 diabetes mellitus, Superoxide dismutase, Matrix metaloptotinase-9 and Interleukin -18. |
| spellingShingle | Shatha R. Moustafa Shawn A. Omar Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes Mellitus Iraqi Journal of Pharmaceutical Sciences Type 2 diabetes mellitus, Superoxide dismutase, Matrix metaloptotinase-9 and Interleukin -18. |
| title | Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes Mellitus |
| title_full | Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes Mellitus |
| title_fullStr | Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes Mellitus |
| title_full_unstemmed | Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes Mellitus |
| title_short | Estimation of Superoxide Dismutase, Matrix-metalloprotinase-9, and Interleukin -18 in Patients with Type Two Diabetes Mellitus |
| title_sort | estimation of superoxide dismutase matrix metalloprotinase 9 and interleukin 18 in patients with type two diabetes mellitus |
| topic | Type 2 diabetes mellitus, Superoxide dismutase, Matrix metaloptotinase-9 and Interleukin -18. |
| url | https://www.bijps.uobaghdad.edu.iq/index.php/bijps/article/view/682 |
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