Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2

Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the immunological profiles of natural killer (NK) cells. However, whether NK antiviral functions are impaired during severe coronavirus disease 2019 (COVID-19) and what host factors modulate these functions remain...

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Bibliographic Details
Main Authors: Pratima Saini, Opeyemi S. Adeniji, Devivasha Bordoloi, Jennifer Kinslow, Jeff Martinson, Danielle M. Parent, Kai Ying Hong, Jane Koshy, Abhijeet J. Kulkarni, Netanel F. Zilberstein, Robert A. Balk, James N. Moy, Leila B. Giron, Russell P. Tracy, Ali Keshavarzian, Kar Muthumani, Alan Landay, David B. Weiner, Mohamed Abdel-Mohsen
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
SARS-CoV-2
COVID-19
natural killer cells
Siglec-7
Siglec-9
antibody-dependent cell cytotoxicity
Online Access:https://journals.asm.org/doi/10.1128/mbio.03393-22

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