Acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex
Abstract Long-term potentiation (LTP) is a form of neuroplasticity commonly implicated in mechanistic models of learning and memory. Acute exercise can boost LTP in the motor cortex, and is associated with a shift in excitation/inhibition (E:I) balance, but whether this extends to other regions such...
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| Format: | Article |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34749-w |
| _version_ | 1827948136942796800 |
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| author | Claire J. Cadwallader Jennifer Steiniger Patrick S. Cooper Shou-Han Zhou Joshua Hendrikse Rachael L. Sumner Ian J. Kirk Trevor T.-J. Chong James P. Coxon |
| author_facet | Claire J. Cadwallader Jennifer Steiniger Patrick S. Cooper Shou-Han Zhou Joshua Hendrikse Rachael L. Sumner Ian J. Kirk Trevor T.-J. Chong James P. Coxon |
| author_sort | Claire J. Cadwallader |
| collection | DOAJ |
| description | Abstract Long-term potentiation (LTP) is a form of neuroplasticity commonly implicated in mechanistic models of learning and memory. Acute exercise can boost LTP in the motor cortex, and is associated with a shift in excitation/inhibition (E:I) balance, but whether this extends to other regions such as the visual cortex is unknown. We investigated the effect of a preceding bout of exercise on LTP induction and the E:I balance in the visual cortex using electroencephalography (EEG). Young adults (N = 20, mean age = 24.20) engaged in 20 min of high-intensity interval training (HIIT) exercise and rest across two counterbalanced sessions. LTP was induced using a high frequency presentation of a visual stimulus; a “visual tetanus”. Established EEG markers of visual LTP, the N1b and P2 component of the visual evoked potential, and an EEG-derived measure of the E:I balance, the aperiodic exponent, were measured before and after the visual tetanus. As expected, there was a potentiation of the N1b following the visual tetanus, with specificity to the tetanised stimulus, and a non-specific potentiation of the P2. These effects were not sensitive to a preceding bout of exercise. However, the E:I balance showed a late shift towards inhibition following the visual tetanus. A preceding bout of exercise resulted in specificity of this E:I balance shift to the tetanised stimulus, that was not seen following rest. This novel finding suggests a possible exercise-induced tuning of the visual cortex to stimulus details following LTP induction. |
| first_indexed | 2024-04-09T12:49:39Z |
| format | Article |
| id | doaj.art-9b326f279bcf4175b2a245c2ae257125 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T12:49:39Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9b326f279bcf4175b2a245c2ae2571252023-05-14T11:16:29ZengNature PortfolioScientific Reports2045-23222023-05-0113111110.1038/s41598-023-34749-wAcute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortexClaire J. Cadwallader0Jennifer Steiniger1Patrick S. Cooper2Shou-Han Zhou3Joshua Hendrikse4Rachael L. Sumner5Ian J. Kirk6Trevor T.-J. Chong7James P. Coxon8School of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash UniversitySchool of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash UniversitySchool of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash UniversitySchool of Psychology, James Cook UniversitySchool of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash UniversitySchool of Pharmacy, The University of AucklandSchool of Psychology, The University of AucklandSchool of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash UniversitySchool of Psychological Sciences, The Turner Institute for Brain and Mental Health, Monash UniversityAbstract Long-term potentiation (LTP) is a form of neuroplasticity commonly implicated in mechanistic models of learning and memory. Acute exercise can boost LTP in the motor cortex, and is associated with a shift in excitation/inhibition (E:I) balance, but whether this extends to other regions such as the visual cortex is unknown. We investigated the effect of a preceding bout of exercise on LTP induction and the E:I balance in the visual cortex using electroencephalography (EEG). Young adults (N = 20, mean age = 24.20) engaged in 20 min of high-intensity interval training (HIIT) exercise and rest across two counterbalanced sessions. LTP was induced using a high frequency presentation of a visual stimulus; a “visual tetanus”. Established EEG markers of visual LTP, the N1b and P2 component of the visual evoked potential, and an EEG-derived measure of the E:I balance, the aperiodic exponent, were measured before and after the visual tetanus. As expected, there was a potentiation of the N1b following the visual tetanus, with specificity to the tetanised stimulus, and a non-specific potentiation of the P2. These effects were not sensitive to a preceding bout of exercise. However, the E:I balance showed a late shift towards inhibition following the visual tetanus. A preceding bout of exercise resulted in specificity of this E:I balance shift to the tetanised stimulus, that was not seen following rest. This novel finding suggests a possible exercise-induced tuning of the visual cortex to stimulus details following LTP induction.https://doi.org/10.1038/s41598-023-34749-w |
| spellingShingle | Claire J. Cadwallader Jennifer Steiniger Patrick S. Cooper Shou-Han Zhou Joshua Hendrikse Rachael L. Sumner Ian J. Kirk Trevor T.-J. Chong James P. Coxon Acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex Scientific Reports |
| title | Acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex |
| title_full | Acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex |
| title_fullStr | Acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex |
| title_full_unstemmed | Acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex |
| title_short | Acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex |
| title_sort | acute exercise as a modifier of neocortical plasticity and aperiodic activity in the visual cortex |
| url | https://doi.org/10.1038/s41598-023-34749-w |
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