PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

Abstract Phosphatidylinositol 3-kinase signaling promotes cell growth and survival and is frequently activated in infiltrative gliomas. Activating mutations in PIK3CA gene are observed in 6–15% of glioblastomas, although their clinical significance is largely undescribed. The objective of this study...

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Bibliographic Details
Main Authors: Shota Tanaka, Tracy T. Batchelor, A. John Iafrate, Dora Dias-Santagata, Darrell R. Borger, Leif W. Ellisen, Daniel Yang, David N. Louis, Daniel P. Cahill, Andrew S. Chi
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Acta Neuropathologica Communications
Subjects:
Dissemination
Glioblastoma
Gliomatosis
Multicentric
PIK3CA
Online Access:http://link.springer.com/article/10.1186/s40478-019-0720-8

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