Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis
BackgroundAndrogenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Previous studies have indicated an association between the gut microbiota and AGA. To delve deeper, we executed a two-sample Mendelian randomization (MR) analysis to investigate the potential causal relat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1360445/full |
| _version_ | 1797230541498482688 |
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| author | Haijing Fu Tianyi Xu Wumei Zhao Leiwei Jiang Shijun Shan Shijun Shan |
| author_facet | Haijing Fu Tianyi Xu Wumei Zhao Leiwei Jiang Shijun Shan Shijun Shan |
| author_sort | Haijing Fu |
| collection | DOAJ |
| description | BackgroundAndrogenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Previous studies have indicated an association between the gut microbiota and AGA. To delve deeper, we executed a two-sample Mendelian randomization (MR) analysis to investigate the potential causal relationship between the gut microbiota and AGA.MethodsA two-sample MR investigation was utilized to delve into the intricate interplay between gut microbiota and AGA. Information regarding 211 gut microbial taxa was sourced from the MiBioGen consortium. The summary statistics of the genome-wide association studies (GWAS) for AGA were obtained from the FinnGen biobank, which included 195 cases and 201,019 controls. Various analytical approaches, including Inverse Variance Weighting (IVW), Weighted Median, MR-Egger, Weighted Mode, and Simple Mode were employed to evaluate the causal impact of gut microbiota on AGA. Sensitivity analyses were subsequently conducted to affirm the robustness of the findings.ResultsA two-sample MR investigation unveiled the genus Olsenella, genus Ruminococcaceae UCG-004, and genus Ruminococcaceae UCG-010 were identified as risk factors associated with AGA. In contrast, the family Acidaminococcaceae and genus Anaerofilum, along with the genus Ruminiclostridium 9, demonstrated a protective effect. The sensitivity analyses provided additional assurance that the findings of the current study were less susceptible to the influence of confounding variables and biases.ConclusionThe MR study has established a link between specific gut microbiota and AGA, offering evidence for the identification of more precisely targeted probiotics. This discovery has the potential to aid in the prevention, control, and reversal of AGA progression. |
| first_indexed | 2024-04-24T15:30:08Z |
| format | Article |
| id | doaj.art-9b3413fd5ea24e5a998d8fbb64d785bd |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T15:30:08Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-9b3413fd5ea24e5a998d8fbb64d785bd2024-04-02T04:30:37ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-04-011510.3389/fmicb.2024.13604451360445Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysisHaijing Fu0Tianyi Xu1Wumei Zhao2Leiwei Jiang3Shijun Shan4Shijun Shan5Department of Dermatology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Dermatology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Dermatology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Dermatology, Guizhou Provincial People’s Hospital, Guiyang, ChinaDepartment of Dermatology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaHangzhou Third People’s Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaBackgroundAndrogenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Previous studies have indicated an association between the gut microbiota and AGA. To delve deeper, we executed a two-sample Mendelian randomization (MR) analysis to investigate the potential causal relationship between the gut microbiota and AGA.MethodsA two-sample MR investigation was utilized to delve into the intricate interplay between gut microbiota and AGA. Information regarding 211 gut microbial taxa was sourced from the MiBioGen consortium. The summary statistics of the genome-wide association studies (GWAS) for AGA were obtained from the FinnGen biobank, which included 195 cases and 201,019 controls. Various analytical approaches, including Inverse Variance Weighting (IVW), Weighted Median, MR-Egger, Weighted Mode, and Simple Mode were employed to evaluate the causal impact of gut microbiota on AGA. Sensitivity analyses were subsequently conducted to affirm the robustness of the findings.ResultsA two-sample MR investigation unveiled the genus Olsenella, genus Ruminococcaceae UCG-004, and genus Ruminococcaceae UCG-010 were identified as risk factors associated with AGA. In contrast, the family Acidaminococcaceae and genus Anaerofilum, along with the genus Ruminiclostridium 9, demonstrated a protective effect. The sensitivity analyses provided additional assurance that the findings of the current study were less susceptible to the influence of confounding variables and biases.ConclusionThe MR study has established a link between specific gut microbiota and AGA, offering evidence for the identification of more precisely targeted probiotics. This discovery has the potential to aid in the prevention, control, and reversal of AGA progression.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1360445/fullandrogenetic alopeciacausal relationshipgeneticgut microbiotaMendelian randomization |
| spellingShingle | Haijing Fu Tianyi Xu Wumei Zhao Leiwei Jiang Shijun Shan Shijun Shan Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis Frontiers in Microbiology androgenetic alopecia causal relationship genetic gut microbiota Mendelian randomization |
| title | Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis |
| title_full | Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis |
| title_fullStr | Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis |
| title_full_unstemmed | Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis |
| title_short | Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis |
| title_sort | roles of gut microbiota in androgenetic alopecia insights from mendelian randomization analysis |
| topic | androgenetic alopecia causal relationship genetic gut microbiota Mendelian randomization |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1360445/full |
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