Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial
Background:. Tranexamic acid (TXA) is used to reduce bleeding in body contouring procedures; however, there are no studies that show the effectiveness of TXA when it is also used in the immediate postoperative period. Methods:. A controlled, randomized, parallel, and open-label clinical trial was ca...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-11-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000005403 |
| _version_ | 1797449509084594176 |
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| author | Jorge Enrique Bayter-Marín, MD Alfredo Hoyos, MD Lázaro Cárdenas-Camarena, MD William Peña-Pinzón, MD Andrés Felipe Bayter-Torres Carlos Andrés Díaz-Díaz, MD Mauricio McCormick-Méndez, MD Erika Liliana Plata-Rueda, MD Claudia Stella Niño-Carreño, MD |
| author_facet | Jorge Enrique Bayter-Marín, MD Alfredo Hoyos, MD Lázaro Cárdenas-Camarena, MD William Peña-Pinzón, MD Andrés Felipe Bayter-Torres Carlos Andrés Díaz-Díaz, MD Mauricio McCormick-Méndez, MD Erika Liliana Plata-Rueda, MD Claudia Stella Niño-Carreño, MD |
| author_sort | Jorge Enrique Bayter-Marín, MD |
| collection | DOAJ |
| description | Background:. Tranexamic acid (TXA) is used to reduce bleeding in body contouring procedures; however, there are no studies that show the effectiveness of TXA when it is also used in the immediate postoperative period.
Methods:. A controlled, randomized, parallel, and open-label clinical trial was carried out in adult patients undergoing liposculpture and/or abdominoplasty. A control group administering presurgical TXA and a study group with presurgical and postsurgical TXA were formed. The decrease in hemoglobin and the incidence of blood transfusions between both groups were compared as well as the possible adverse effects of TXA.
Results:. Four hundred twenty-seven subjects were included, 208 (48.7%) in the control group and 219 (51.3%) in the study group. The median age was 34 years (interquartile range 28–42). Median postoperative hemoglobin levels at 24 hours were similar in both groups (study 11.3 g/dL versus control 11.1 g/dL, P = 0.07); however, at 72 hours, postoperative hemoglobin was higher in the study group versus control (10.8 versus 10.0 g/dL, P ≤ 0.001). The incidence of transfusions at 72 hours was 1.8% in the study group and 8.6% in the control group, for a risk ratio of 0.21 (95% confidence interval 0.07–0.61). There were no adverse or thromboembolic events.
Conclusion:. TXA proved to be more effective in reducing intra- and postsurgical bleeding and the need for transfusions, when used preoperatively and continued for 48 hours after surgery, than when used only preoperatively, without reporting adverse or thromboembolic effects. |
| first_indexed | 2024-03-09T14:27:02Z |
| format | Article |
| id | doaj.art-9b34956ec64e4da3a6aab0f7af2d6630 |
| institution | Directory Open Access Journal |
| issn | 2169-7574 |
| language | English |
| last_indexed | 2024-03-09T14:27:02Z |
| publishDate | 2023-11-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj.art-9b34956ec64e4da3a6aab0f7af2d66302023-11-28T07:10:12ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742023-11-011111e540310.1097/GOX.0000000000005403202311000-00031Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical TrialJorge Enrique Bayter-Marín, MD0Alfredo Hoyos, MD1Lázaro Cárdenas-Camarena, MD2William Peña-Pinzón, MD3Andrés Felipe Bayter-Torres4Carlos Andrés Díaz-Díaz, MD5Mauricio McCormick-Méndez, MD6Erika Liliana Plata-Rueda, MD7Claudia Stella Niño-Carreño, MD8From the * Universidad Industrial de Santander§ Elysium Aesthetics, Bogota, Colombia¶ INNOVARE, Specialized Plastic Surgery, Zapopan, Jalisco, Mexico‖ Department of Anesthesiology and Perioperative Medicine, Fundación Universitaria Sanitas, Bucaramanga, Colombia** Universidad Industrial de Santander, Bucaramanga, Colombia†† Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia‡‡ Department of Anesthesiology, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia§§ Department of Anesthesiology and Perioperative Medicine, Universidad Industrial de Santander, Fundación Universitaria Sanitas, Bucaramanga, Colombia.‖ Department of Anesthesiology and Perioperative Medicine, Fundación Universitaria Sanitas, Bucaramanga, ColombiaBackground:. Tranexamic acid (TXA) is used to reduce bleeding in body contouring procedures; however, there are no studies that show the effectiveness of TXA when it is also used in the immediate postoperative period. Methods:. A controlled, randomized, parallel, and open-label clinical trial was carried out in adult patients undergoing liposculpture and/or abdominoplasty. A control group administering presurgical TXA and a study group with presurgical and postsurgical TXA were formed. The decrease in hemoglobin and the incidence of blood transfusions between both groups were compared as well as the possible adverse effects of TXA. Results:. Four hundred twenty-seven subjects were included, 208 (48.7%) in the control group and 219 (51.3%) in the study group. The median age was 34 years (interquartile range 28–42). Median postoperative hemoglobin levels at 24 hours were similar in both groups (study 11.3 g/dL versus control 11.1 g/dL, P = 0.07); however, at 72 hours, postoperative hemoglobin was higher in the study group versus control (10.8 versus 10.0 g/dL, P ≤ 0.001). The incidence of transfusions at 72 hours was 1.8% in the study group and 8.6% in the control group, for a risk ratio of 0.21 (95% confidence interval 0.07–0.61). There were no adverse or thromboembolic events. Conclusion:. TXA proved to be more effective in reducing intra- and postsurgical bleeding and the need for transfusions, when used preoperatively and continued for 48 hours after surgery, than when used only preoperatively, without reporting adverse or thromboembolic effects.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000005403 |
| spellingShingle | Jorge Enrique Bayter-Marín, MD Alfredo Hoyos, MD Lázaro Cárdenas-Camarena, MD William Peña-Pinzón, MD Andrés Felipe Bayter-Torres Carlos Andrés Díaz-Díaz, MD Mauricio McCormick-Méndez, MD Erika Liliana Plata-Rueda, MD Claudia Stella Niño-Carreño, MD Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial Plastic and Reconstructive Surgery, Global Open |
| title | Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial |
| title_full | Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial |
| title_fullStr | Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial |
| title_full_unstemmed | Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial |
| title_short | Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial |
| title_sort | effectiveness of tranexamic acid in the postoperative period in body contour surgery randomized clinical trial |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000005403 |
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