Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement

Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement

Background Patients with repair of tetralogy of Fallot (rToF) who are approaching adulthood often exhibit pulmonary valve regurgitation, leading to right ventricle (RV) dilatation and dysfunction. The regurgitation can be corrected by pulmonary valve replacement (PVR), but the optimal surgical timin...

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Bibliografske podrobnosti
Main Authors: Daniel Brayson, So‐Jin Holohan, Sonya C. Bardswell, Matthew Arno, Han Lu, Hanna K. Jensen, Phan Kiet Tran, Javier Barallobre‐Barreiro, Manuel Mayr, Cristobal G. dos Remedios, Victor T. Tsang, Alessandra Frigiola, Jonathan C. Kentish
Format: Article
Jezik:English
Izdano: Wiley 2020-08-01
Serija:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Teme:
extracellular matrix
myofibril
pulmonary valve replacement
small leucine rich proteoglycan
tetralogy of Fallot
Online dostop:https://www.ahajournals.org/doi/10.1161/JAHA.119.015342

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.015342

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