Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clock

Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clock

DNA aptamers can bind specifically to biomolecules to modify their function, potentially making them ideal oligonucleotide therapeutics. Herein, we screened for DNA aptamer of melanopsin (OPN4), a blue-light photopigment in the retina, which plays a key role using light signals to reset the phase of...

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Bibliographic Details
Main Authors: Kazuo Nakazawa, Minako Matsuo, Yo Kikuchi, Yoshihiro Nakajima, Rika Numano
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Neuroscience
Subjects:
melanopsin (OPN4)
DNA aptamer
Melapt
circadian rhythm
molecular clock
phase shift
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1186677/full

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