Practical Prediction Model for Ovarian Insufficiency after Radiation
Abstract Objective The present study aimed to develop a useful mathematical model that predicts the age at which premature ovarian insufficiency might occur after teletherapy radiation. A diagnosis of premature or early menopause has physical and psychological consequences, so women may need suppor...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2022-08-01
|
| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000600573&tlng=en |
| _version_ | 1828422127018049536 |
|---|---|
| author | Gabriel Oliveira Bernardes Gil Cassiano Asano Warne Pedro de Andrade Maria Luísa Braga Vieira Gil Eduardo Batista Cândido Marcos Regalin Izabella Nobre Queiroz Farley Soares Cantídio Darly Gomes Soares Delfino Agnaldo Lopes Silva-Filho |
| author_facet | Gabriel Oliveira Bernardes Gil Cassiano Asano Warne Pedro de Andrade Maria Luísa Braga Vieira Gil Eduardo Batista Cândido Marcos Regalin Izabella Nobre Queiroz Farley Soares Cantídio Darly Gomes Soares Delfino Agnaldo Lopes Silva-Filho |
| author_sort | Gabriel Oliveira Bernardes Gil |
| collection | DOAJ |
| description | Abstract Objective The present study aimed to develop a useful mathematical model that predicts the age at which premature ovarian insufficiency might occur after teletherapy radiation. A diagnosis of premature or early menopause has physical and psychological consequences, so women may need support and long-term medical follow-up. Methods To correlate ovarian radiation dose with ovarian function, we used the formula described by Wallace et al.: √g(z) = 10(2-0,15z), where “g(z)” and “z” represent oocyte survival rate and the radiation dose (in Gray), respectively. By simulating different ages and doses, we observed a pattern that could be used to simplify the relationship between radiation dose and remaining time of ovarian function. Results We obtained a linear function between ovarian radiation dose and loss of ovarian function (LOF) that is the percentage of decrease in the time to the ovarian failure compared with the time expected for a woman at the same age without irradiation exposition. For patients <40 years old and with ovarian radiation doses < 5 Gy, the equation LOF = 2.70 + (11.08 × Dose) can be applied to estimate the decrease in time to premature ovarian insufficiency. Conclusion The present study reports a practicable theoretical method to estimate the loss of ovarian function. These findings can potentially improve the management and counseling of young women patients submitted to radiotherapy during their reproductive years. |
| first_indexed | 2024-12-10T15:43:11Z |
| format | Article |
| id | doaj.art-9b36ad0c7bc342df8e6d21ed93bf7d26 |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-12-10T15:43:11Z |
| publishDate | 2022-08-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-9b36ad0c7bc342df8e6d21ed93bf7d262022-12-22T01:43:03ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032022-08-0144657357710.1055/s-0042-1746199Practical Prediction Model for Ovarian Insufficiency after RadiationGabriel Oliveira Bernardes Gilhttps://orcid.org/0000-0002-6284-5899Cassiano Asanohttps://orcid.org/0000-0002-9845-2966Warne Pedro de Andradehttps://orcid.org/0000-0002-1056-6169Maria Luísa Braga Vieira Gilhttps://orcid.org/0000-0001-9510-9444Eduardo Batista Cândidohttps://orcid.org/0000-0001-6496-6654Marcos Regalinhttps://orcid.org/0000-0002-1649-7440Izabella Nobre Queirozhttps://orcid.org/0000-0002-0449-1893Farley Soares Cantídiohttps://orcid.org/0000-0002-7145-9869Darly Gomes Soares Delfinohttps://orcid.org/0000-0002-3544-4969Agnaldo Lopes Silva-Filhohttps://orcid.org/0000-0002-8486-7861Abstract Objective The present study aimed to develop a useful mathematical model that predicts the age at which premature ovarian insufficiency might occur after teletherapy radiation. A diagnosis of premature or early menopause has physical and psychological consequences, so women may need support and long-term medical follow-up. Methods To correlate ovarian radiation dose with ovarian function, we used the formula described by Wallace et al.: √g(z) = 10(2-0,15z), where “g(z)” and “z” represent oocyte survival rate and the radiation dose (in Gray), respectively. By simulating different ages and doses, we observed a pattern that could be used to simplify the relationship between radiation dose and remaining time of ovarian function. Results We obtained a linear function between ovarian radiation dose and loss of ovarian function (LOF) that is the percentage of decrease in the time to the ovarian failure compared with the time expected for a woman at the same age without irradiation exposition. For patients <40 years old and with ovarian radiation doses < 5 Gy, the equation LOF = 2.70 + (11.08 × Dose) can be applied to estimate the decrease in time to premature ovarian insufficiency. Conclusion The present study reports a practicable theoretical method to estimate the loss of ovarian function. These findings can potentially improve the management and counseling of young women patients submitted to radiotherapy during their reproductive years.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000600573&tlng=enradiotherapyovarian insufficiencyovarian functionovarian radiation |
| spellingShingle | Gabriel Oliveira Bernardes Gil Cassiano Asano Warne Pedro de Andrade Maria Luísa Braga Vieira Gil Eduardo Batista Cândido Marcos Regalin Izabella Nobre Queiroz Farley Soares Cantídio Darly Gomes Soares Delfino Agnaldo Lopes Silva-Filho Practical Prediction Model for Ovarian Insufficiency after Radiation Revista Brasileira de Ginecologia e Obstetrícia radiotherapy ovarian insufficiency ovarian function ovarian radiation |
| title | Practical Prediction Model for Ovarian Insufficiency after Radiation |
| title_full | Practical Prediction Model for Ovarian Insufficiency after Radiation |
| title_fullStr | Practical Prediction Model for Ovarian Insufficiency after Radiation |
| title_full_unstemmed | Practical Prediction Model for Ovarian Insufficiency after Radiation |
| title_short | Practical Prediction Model for Ovarian Insufficiency after Radiation |
| title_sort | practical prediction model for ovarian insufficiency after radiation |
| topic | radiotherapy ovarian insufficiency ovarian function ovarian radiation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000600573&tlng=en |
| work_keys_str_mv | AT gabrieloliveirabernardesgil practicalpredictionmodelforovarianinsufficiencyafterradiation AT cassianoasano practicalpredictionmodelforovarianinsufficiencyafterradiation AT warnepedrodeandrade practicalpredictionmodelforovarianinsufficiencyafterradiation AT marialuisabragavieiragil practicalpredictionmodelforovarianinsufficiencyafterradiation AT eduardobatistacandido practicalpredictionmodelforovarianinsufficiencyafterradiation AT marcosregalin practicalpredictionmodelforovarianinsufficiencyafterradiation AT izabellanobrequeiroz practicalpredictionmodelforovarianinsufficiencyafterradiation AT farleysoarescantidio practicalpredictionmodelforovarianinsufficiencyafterradiation AT darlygomessoaresdelfino practicalpredictionmodelforovarianinsufficiencyafterradiation AT agnaldolopessilvafilho practicalpredictionmodelforovarianinsufficiencyafterradiation |