Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization
Abstract Age‐related macular degeneration in its neovascular form (NV AMD) is the leading cause of vision loss among adults above the age of 60. Epidemiological data suggest that in men, overall abdominal obesity is the second most important environmental risk factor after smoking for progression to...
| 主要な著者: | , , , , , , |
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| フォーマット: | 論文 |
| 言語: | English |
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Springer Nature
2016-11-01
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| シリーズ: | EMBO Molecular Medicine |
| 主題: | |
| オンライン･アクセス: | https://doi.org/10.15252/emmm.201606531 |
| _version_ | 1827059777327333376 |
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| author | Elisabeth MMA Andriessen Ariel M Wilson Gaelle Mawambo Agnieszka Dejda Khalil Miloudi Florian Sennlaub Przemyslaw Sapieha |
| author_facet | Elisabeth MMA Andriessen Ariel M Wilson Gaelle Mawambo Agnieszka Dejda Khalil Miloudi Florian Sennlaub Przemyslaw Sapieha |
| author_sort | Elisabeth MMA Andriessen |
| collection | DOAJ |
| description | Abstract Age‐related macular degeneration in its neovascular form (NV AMD) is the leading cause of vision loss among adults above the age of 60. Epidemiological data suggest that in men, overall abdominal obesity is the second most important environmental risk factor after smoking for progression to late‐stage NV AMD. To date, the mechanisms that underscore this observation remain ill‐defined. Given the impact of high‐fat diets on gut microbiota, we investigated whether commensal microbes influence the evolution of AMD. Using mouse models of NV AMD, microbiotal transplants, and other paradigms that modify the gut microbiome, we uncoupled weight gain from confounding factors and demonstrate that high‐fat diets exacerbate choroidal neovascularization (CNV) by altering gut microbiota. Gut dysbiosis leads to heightened intestinal permeability and chronic low‐grade inflammation characteristic of inflammaging with elevated production of IL‐6, IL‐1β, TNF‐α, and VEGF‐A that ultimately aggravate pathological angiogenesis. |
| first_indexed | 2024-03-13T03:11:03Z |
| format | Article |
| id | doaj.art-9b36b64e17c84d718e52bf1aebe8c97c |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2025-02-18T18:46:52Z |
| publishDate | 2016-11-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-9b36b64e17c84d718e52bf1aebe8c97c2024-10-20T11:39:23ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842016-11-018121366137910.15252/emmm.201606531Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularizationElisabeth MMA Andriessen0Ariel M Wilson1Gaelle Mawambo2Agnieszka Dejda3Khalil Miloudi4Florian Sennlaub5Przemyslaw Sapieha6Department of Biomedical Sciences, Maisonneuve‐Rosemont Hospital Research Centre, University of MontrealDepartment of Engineering Physics, Laser Processing and Plasmonics Laboratory, École Polytechnique de MontréalDepartment of Biochemistry, Maisonneuve‐Rosemont Hospital Research Centre, University of MontrealDepartment of Biochemistry, Maisonneuve‐Rosemont Hospital Research Centre, University of MontrealDepartment of Neurology‐Neurosurgery, McGill UniversityINSERM, U 968, Sorbonne Universités, Université Pierre et Marie Curie Paris 06, Unité Mixte de Recherche S 968, Institut de la Vision, CNRS, Unité Mixte de RechercheDepartment of Biomedical Sciences, Maisonneuve‐Rosemont Hospital Research Centre, University of MontrealAbstract Age‐related macular degeneration in its neovascular form (NV AMD) is the leading cause of vision loss among adults above the age of 60. Epidemiological data suggest that in men, overall abdominal obesity is the second most important environmental risk factor after smoking for progression to late‐stage NV AMD. To date, the mechanisms that underscore this observation remain ill‐defined. Given the impact of high‐fat diets on gut microbiota, we investigated whether commensal microbes influence the evolution of AMD. Using mouse models of NV AMD, microbiotal transplants, and other paradigms that modify the gut microbiome, we uncoupled weight gain from confounding factors and demonstrate that high‐fat diets exacerbate choroidal neovascularization (CNV) by altering gut microbiota. Gut dysbiosis leads to heightened intestinal permeability and chronic low‐grade inflammation characteristic of inflammaging with elevated production of IL‐6, IL‐1β, TNF‐α, and VEGF‐A that ultimately aggravate pathological angiogenesis.https://doi.org/10.15252/emmm.201606531age‐related macular degenerationangiogenesisgut microbiotainflammagingobesity |
| spellingShingle | Elisabeth MMA Andriessen Ariel M Wilson Gaelle Mawambo Agnieszka Dejda Khalil Miloudi Florian Sennlaub Przemyslaw Sapieha Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization EMBO Molecular Medicine age‐related macular degeneration angiogenesis gut microbiota inflammaging obesity |
| title | Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization |
| title_full | Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization |
| title_fullStr | Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization |
| title_full_unstemmed | Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization |
| title_short | Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization |
| title_sort | gut microbiota influences pathological angiogenesis in obesity driven choroidal neovascularization |
| topic | age‐related macular degeneration angiogenesis gut microbiota inflammaging obesity |
| url | https://doi.org/10.15252/emmm.201606531 |
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