Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery

Abstract While several COVID-19 vaccines have been in use, more effective and durable vaccines are needed to combat the ongoing COVID-19 pandemic. Here, we report highly immunogenic self-assembling SARS-CoV-2 spike-HBsAg nanoparticles displaying a six-proline-stabilized WA1 (wild type, WT) spike S6P...

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Bibliographic Details
Main Authors: Cuiping Liu, Lingshu Wang, Jonah S. Merriam, Wei Shi, Eun Sung Yang, Yi Zhang, Man Chen, Wing-Pui Kong, Cheng Cheng, Yaroslav Tsybovsky, Tyler Stephens, Raffaello Verardi, Kwanyee Leung, Cody Stein, Adam S. Olia, Darcy R. Harris, Misook Choe, Baoshan Zhang, Barney S. Graham, Peter D. Kwong, Richard A. Koup, Amarendra Pegu, John R. Mascola
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00707-w

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