Screening and Identification of Microbial Derivatives for Inhibiting Legumain: An In silico Approach
Legumain an asparginyl endopeptidase expressed by both tumor cells and cells present in tumor microenvironment is an ideal therapeutic target for development of cancer therapies due to its correlation with high metastasis and invasion in various cancers. Microbial derivatives have demonstrated ma...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Journal of Pure and Applied Microbiology
2018-09-01
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| Series: | Journal of Pure and Applied Microbiology |
| Subjects: | |
| Online Access: | https://microbiologyjournal.org/screening-and-identification-of-microbial-derivatives-for-inhibiting-legumain-an-in-silico-approach/ |
| Summary: | Legumain an asparginyl endopeptidase expressed by both tumor cells and cells present
in tumor microenvironment is an ideal therapeutic target for development of cancer therapies
due to its correlation with high metastasis and invasion in various cancers. Microbial derivatives
have demonstrated many pharmacological properties such as antioxidant, anti-inflammatory,
anti tumor and immunostimulatory activities.In the current study, 541 microbial derivatives
were screened for their potential to inhibit legumain using Lib dock .Out of 541 compounds
screened we have identified 55 microbial derivatives which showed binding to legumain by
docking. Molecular interaction analysis of top five docked derivatives revealed the interaction
of derivatives with the catalytic residues of legumain. These compounds need to be further
evaluated in vitro and in vivo for Legumain inhibition and ultimately cancer regression. |
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| ISSN: | 0973-7510 2581-690X |