A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery
Abstract A crucial component of the musculoskeletal system, the tendon is one of the most commonly injured tissues in the body. In severe cases, the ruptured tendon leads to permanent dysfunction. Although many efforts have been devoted to seeking a safe and efficient treatment for enhancing tendon...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Bioengineering & Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/btm2.10355 |
| _version_ | 1797270787213754368 |
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| author | Xue Xu Yulong Zhang Pin Ha Yao Chen Chenshuang Li Emily Yen Yuxing Bai Renji Chen Benjamin M. Wu Andrew Da Lio Kang Ting Chia Soo Zhong Zheng |
| author_facet | Xue Xu Yulong Zhang Pin Ha Yao Chen Chenshuang Li Emily Yen Yuxing Bai Renji Chen Benjamin M. Wu Andrew Da Lio Kang Ting Chia Soo Zhong Zheng |
| author_sort | Xue Xu |
| collection | DOAJ |
| description | Abstract A crucial component of the musculoskeletal system, the tendon is one of the most commonly injured tissues in the body. In severe cases, the ruptured tendon leads to permanent dysfunction. Although many efforts have been devoted to seeking a safe and efficient treatment for enhancing tendon healing, currently existing treatments have not yet achieved a major clinical improvement. Here, an injectable granular hyaluronic acid (gHA)‐hydrogel is engineered to deliver fibromodulin (FMOD)—a bioactive extracellular matrix (ECM) that enhances tenocyte mobility and optimizes the surrounding ECM assembly for tendon healing. The FMOD‐releasing granular HA (FMOD/gHA)‐hydrogel exhibits unique characteristics that are desired for both patients and health providers, such as permitting a microinvasive application and displaying a burst‐to‐sustained two‐phase release of FMOD, which leads to a prompt FMOD delivery followed by a constant dose‐maintaining period. Importantly, the generated FMOD‐releasing granular HA hydrogel significantly augmented tendon‐healing in a fully‐ruptured rat's Achilles tendon model histologically, mechanically, and functionally. Particularly, the breaking strength of the wounded tendon and the gait performance of treated rats returns to the same normal level as the healthy controls. In summary, a novel effective FMOD/gHA‐hydrogel is developed in response to the urgent demand for promoting tendon healing. |
| first_indexed | 2024-04-25T02:09:49Z |
| format | Article |
| id | doaj.art-9b3bb76f264243f7a40b971d23ddd8f6 |
| institution | Directory Open Access Journal |
| issn | 2380-6761 |
| language | English |
| last_indexed | 2024-04-25T02:09:49Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj.art-9b3bb76f264243f7a40b971d23ddd8f62024-03-07T12:20:54ZengWileyBioengineering & Translational Medicine2380-67612023-01-0181n/an/a10.1002/btm2.10355A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recoveryXue Xu0Yulong Zhang1Pin Ha2Yao Chen3Chenshuang Li4Emily Yen5Yuxing Bai6Renji Chen7Benjamin M. Wu8Andrew Da Lio9Kang Ting10Chia Soo11Zhong Zheng12Department of Oral and Maxillofacial Plastic and Traumatic Surgery Beijing Stomatological Hospital of Capital Medical University Beijing ChinaSchool of Dentistry University of California Los Angeles California USADivision of Plastic and Reconstructive Surgery David Geffen School of Medicine, University of California Los Angeles California USASchool of Dentistry University of California Los Angeles California USADepartment of Orthodontics School of Dental Medicine, University of Pennsylvania Philadelphia Pennsylvania USAArcadia High School Arcadia California USADepartment of Orthodontics Beijing Stomatological Hospital of Capital Medical University Beijing ChinaDepartment of Oral and Maxillofacial Plastic and Traumatic Surgery Beijing Stomatological Hospital of Capital Medical University Beijing ChinaSchool of Dentistry University of California Los Angeles California USADivision of Plastic and Reconstructive Surgery David Geffen School of Medicine, University of California Los Angeles California USAForsyth Research Institute Harvard University Cambridge Massachusetts USADivision of Plastic and Reconstructive Surgery, Department of Orthopaedic Surgery The Orthopaedic Hospital Research Center, University of California Los Angeles California USADivision of Plastic and Reconstructive Surgery David Geffen School of Medicine, University of California Los Angeles California USAAbstract A crucial component of the musculoskeletal system, the tendon is one of the most commonly injured tissues in the body. In severe cases, the ruptured tendon leads to permanent dysfunction. Although many efforts have been devoted to seeking a safe and efficient treatment for enhancing tendon healing, currently existing treatments have not yet achieved a major clinical improvement. Here, an injectable granular hyaluronic acid (gHA)‐hydrogel is engineered to deliver fibromodulin (FMOD)—a bioactive extracellular matrix (ECM) that enhances tenocyte mobility and optimizes the surrounding ECM assembly for tendon healing. The FMOD‐releasing granular HA (FMOD/gHA)‐hydrogel exhibits unique characteristics that are desired for both patients and health providers, such as permitting a microinvasive application and displaying a burst‐to‐sustained two‐phase release of FMOD, which leads to a prompt FMOD delivery followed by a constant dose‐maintaining period. Importantly, the generated FMOD‐releasing granular HA hydrogel significantly augmented tendon‐healing in a fully‐ruptured rat's Achilles tendon model histologically, mechanically, and functionally. Particularly, the breaking strength of the wounded tendon and the gait performance of treated rats returns to the same normal level as the healthy controls. In summary, a novel effective FMOD/gHA‐hydrogel is developed in response to the urgent demand for promoting tendon healing.https://doi.org/10.1002/btm2.10355fibromodulinfunctional reconstructiongranular hydrogelhydrogel microparticlestendon wound healing |
| spellingShingle | Xue Xu Yulong Zhang Pin Ha Yao Chen Chenshuang Li Emily Yen Yuxing Bai Renji Chen Benjamin M. Wu Andrew Da Lio Kang Ting Chia Soo Zhong Zheng A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery Bioengineering & Translational Medicine fibromodulin functional reconstruction granular hydrogel hydrogel microparticles tendon wound healing |
| title | A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery |
| title_full | A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery |
| title_fullStr | A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery |
| title_full_unstemmed | A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery |
| title_short | A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery |
| title_sort | novel injectable fibromodulin releasing granular hydrogel for tendon healing and functional recovery |
| topic | fibromodulin functional reconstruction granular hydrogel hydrogel microparticles tendon wound healing |
| url | https://doi.org/10.1002/btm2.10355 |
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