Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies
There is a paradoxical relationship between obesity, as measured by BMI, and many types of cancer, including non-small-cell lung cancer. Obese non-small-cell lung cancer patients have been shown to fare better than their non-obese counterparts. To analyze the multifaceted effects of obesity on oncol...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/6/1440 |
| _version_ | 1797446979992682496 |
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| author | Lindsay Joyce Nitsche Sarbajit Mukherjee Kareena Cheruvu Cathleen Krabak Rohit Rachala Kalyan Ratnakaram Priyanka Sharma Maddy Singh Sai Yendamuri |
| author_facet | Lindsay Joyce Nitsche Sarbajit Mukherjee Kareena Cheruvu Cathleen Krabak Rohit Rachala Kalyan Ratnakaram Priyanka Sharma Maddy Singh Sai Yendamuri |
| author_sort | Lindsay Joyce Nitsche |
| collection | DOAJ |
| description | There is a paradoxical relationship between obesity, as measured by BMI, and many types of cancer, including non-small-cell lung cancer. Obese non-small-cell lung cancer patients have been shown to fare better than their non-obese counterparts. To analyze the multifaceted effects of obesity on oncologic outcomes, we reviewed the literature on the obesity paradox, methods to measure adiposity, the obesity-related derangements in immunology and metabolism, and the oncologic impact of confounding variables such as gender, smoking, and concomitant medications such as statins and metformin. We analyzed how these aspects may contribute to the obesity paradox and cancer outcomes with a focus on lung cancer. We concluded that the use of BMI to measure adiposity is limited and should be replaced by a method that can differentiate abdominal obesity. We also concluded that the concomitant metabolic and immunologic derangements caused by obesity contribute to the obesity paradox. Medications, gender, and smoking are additional variables that impact oncologic outcomes, and further research needs to be performed to solidify the mechanisms. |
| first_indexed | 2024-03-09T13:48:19Z |
| format | Article |
| id | doaj.art-9b3bbcc1310246a385a0012879c122c5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:48:19Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9b3bbcc1310246a385a0012879c122c52023-11-30T20:55:32ZengMDPI AGCancers2072-66942022-03-01146144010.3390/cancers14061440Exploring the Impact of the Obesity Paradox on Lung Cancer and Other MalignanciesLindsay Joyce Nitsche0Sarbajit Mukherjee1Kareena Cheruvu2Cathleen Krabak3Rohit Rachala4Kalyan Ratnakaram5Priyanka Sharma6Maddy Singh7Sai Yendamuri8Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USADepartment of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USAThere is a paradoxical relationship between obesity, as measured by BMI, and many types of cancer, including non-small-cell lung cancer. Obese non-small-cell lung cancer patients have been shown to fare better than their non-obese counterparts. To analyze the multifaceted effects of obesity on oncologic outcomes, we reviewed the literature on the obesity paradox, methods to measure adiposity, the obesity-related derangements in immunology and metabolism, and the oncologic impact of confounding variables such as gender, smoking, and concomitant medications such as statins and metformin. We analyzed how these aspects may contribute to the obesity paradox and cancer outcomes with a focus on lung cancer. We concluded that the use of BMI to measure adiposity is limited and should be replaced by a method that can differentiate abdominal obesity. We also concluded that the concomitant metabolic and immunologic derangements caused by obesity contribute to the obesity paradox. Medications, gender, and smoking are additional variables that impact oncologic outcomes, and further research needs to be performed to solidify the mechanisms.https://www.mdpi.com/2072-6694/14/6/1440obesityBMIlung cancerobesity paradox |
| spellingShingle | Lindsay Joyce Nitsche Sarbajit Mukherjee Kareena Cheruvu Cathleen Krabak Rohit Rachala Kalyan Ratnakaram Priyanka Sharma Maddy Singh Sai Yendamuri Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies Cancers obesity BMI lung cancer obesity paradox |
| title | Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies |
| title_full | Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies |
| title_fullStr | Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies |
| title_full_unstemmed | Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies |
| title_short | Exploring the Impact of the Obesity Paradox on Lung Cancer and Other Malignancies |
| title_sort | exploring the impact of the obesity paradox on lung cancer and other malignancies |
| topic | obesity BMI lung cancer obesity paradox |
| url | https://www.mdpi.com/2072-6694/14/6/1440 |
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