Combined inhibition of bile salt synthesis and intestinal uptake reduces cholestatic liver damage and colonic bile salts in mice
Background & Aims: Intestine-restricted inhibitors of the apical sodium-dependent bile acid transporter (ASBT, or ileal bile acid transporter) are approved as treatment for several inheritable forms of cholestasis but are also associated with abdominal complaints and diarrhoea. Furthermore,...
Main Authors: | Roni F. Kunst, Isabelle Bolt, Rychon D.J. van Dasselaar, Bart A. Nijmeijer, Ulrich Beuers, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2024-01-01
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Series: | JHEP Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555923002483 |
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