Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study
<p>Abstract</p> <p>Background</p> <p>Although it is believed that fish ω-3 fatty acids may decrease breast cancer risk, epidemiological evidence has been inconclusive. This study examined the association between fish and fish ω-3 fatty acids intake with the risk of brea...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-06-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/9/216 |
| _version_ | 1811249389295894528 |
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| author | Lee Keun Kang Han-Sung Ro Jungsil Sung Mi-Kyung Shin Aesun Lim Sun-Young Kim Jeongseon Kim Seok-Won Lee Eun-Sook |
| author_facet | Lee Keun Kang Han-Sung Ro Jungsil Sung Mi-Kyung Shin Aesun Lim Sun-Young Kim Jeongseon Kim Seok-Won Lee Eun-Sook |
| author_sort | Lee Keun |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Although it is believed that fish ω-3 fatty acids may decrease breast cancer risk, epidemiological evidence has been inconclusive. This study examined the association between fish and fish ω-3 fatty acids intake with the risk of breast cancer in a case-control study of Korean women.</p> <p>Methods</p> <p>We recruited 358 incident breast cancer patients and 360 controls with no history of malignant neoplasm from the National Cancer Center Hospital between July 2007 and April 2008. The study participants were given a 103-item food intake frequency questionnaire to determine their dietary consumption of fish (fatty and lean fish) and ω-3 fatty acids derived from fish (eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)).</p> <p>Results</p> <p>Using a multivariate logistic regression model, high intake of fatty fish was associated with a reduced risk for breast cancer in both pre- and postmenopausal women (OR [95% CI] for highest vs. lowest intake quartiles, <it>p </it>for trend: 0.19 [0.08 to 0.45], <it>p </it>< 0.001 for premenopausal women, 0.27 [0.11 to 0.66], <it>p </it>= 0.005 for postmenopausal women). Similarly, reductions in breast cancer risk were observed among postmenopausal subjects who consumed more than 0.101 g of EPA (OR [95% CI]: 0.38 [0.15 to 0.96]) and 0.213 g of DHA (OR [95% CI]: 0.32 [0.13 to 0.82]) from fish per day compared to the reference group who consumed less than 0.014 g of EPA and 0.037 g of DHA per day. Among premenopausal women, there was a significant reduction in breast cancer risk for the highest intake quartiles of ω-3 fatty acids (ORs [95% CI]: 0.46 [0.22 to 0.96]), compared to the reference group who consumed the lowest quartile of intake.</p> <p>Conclusion</p> <p>These results suggest that high consumption of fatty fish is associated with a reduced risk for breast cancer, and that the intake of ω-3 fatty acids from fish is inversely associated with postmenopausal breast cancer risk.</p> |
| first_indexed | 2024-04-12T15:45:40Z |
| format | Article |
| id | doaj.art-9b3c4a92cc014b41aa975fac60173e5d |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-12T15:45:40Z |
| publishDate | 2009-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-9b3c4a92cc014b41aa975fac60173e5d2022-12-22T03:26:40ZengBMCBMC Cancer1471-24072009-06-019121610.1186/1471-2407-9-216Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control studyLee KeunKang Han-SungRo JungsilSung Mi-KyungShin AesunLim Sun-YoungKim JeongseonKim Seok-WonLee Eun-Sook<p>Abstract</p> <p>Background</p> <p>Although it is believed that fish ω-3 fatty acids may decrease breast cancer risk, epidemiological evidence has been inconclusive. This study examined the association between fish and fish ω-3 fatty acids intake with the risk of breast cancer in a case-control study of Korean women.</p> <p>Methods</p> <p>We recruited 358 incident breast cancer patients and 360 controls with no history of malignant neoplasm from the National Cancer Center Hospital between July 2007 and April 2008. The study participants were given a 103-item food intake frequency questionnaire to determine their dietary consumption of fish (fatty and lean fish) and ω-3 fatty acids derived from fish (eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)).</p> <p>Results</p> <p>Using a multivariate logistic regression model, high intake of fatty fish was associated with a reduced risk for breast cancer in both pre- and postmenopausal women (OR [95% CI] for highest vs. lowest intake quartiles, <it>p </it>for trend: 0.19 [0.08 to 0.45], <it>p </it>< 0.001 for premenopausal women, 0.27 [0.11 to 0.66], <it>p </it>= 0.005 for postmenopausal women). Similarly, reductions in breast cancer risk were observed among postmenopausal subjects who consumed more than 0.101 g of EPA (OR [95% CI]: 0.38 [0.15 to 0.96]) and 0.213 g of DHA (OR [95% CI]: 0.32 [0.13 to 0.82]) from fish per day compared to the reference group who consumed less than 0.014 g of EPA and 0.037 g of DHA per day. Among premenopausal women, there was a significant reduction in breast cancer risk for the highest intake quartiles of ω-3 fatty acids (ORs [95% CI]: 0.46 [0.22 to 0.96]), compared to the reference group who consumed the lowest quartile of intake.</p> <p>Conclusion</p> <p>These results suggest that high consumption of fatty fish is associated with a reduced risk for breast cancer, and that the intake of ω-3 fatty acids from fish is inversely associated with postmenopausal breast cancer risk.</p>http://www.biomedcentral.com/1471-2407/9/216 |
| spellingShingle | Lee Keun Kang Han-Sung Ro Jungsil Sung Mi-Kyung Shin Aesun Lim Sun-Young Kim Jeongseon Kim Seok-Won Lee Eun-Sook Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study BMC Cancer |
| title | Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study |
| title_full | Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study |
| title_fullStr | Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study |
| title_full_unstemmed | Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study |
| title_short | Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study |
| title_sort | fatty fish and fish omega 3 fatty acid intakes decrease the breast cancer risk a case control study |
| url | http://www.biomedcentral.com/1471-2407/9/216 |
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