A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression
Depression is a common mental disorder that affects many people worldwide, while a significant proportion of patients remain non-responsive to antidepressant medications. Alternative treatment options such as ketamine therapy and repetitive transcranial magnetic stimulation (rTMS) therapy are offere...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.784830/full |
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| author | Georgios Mikellides Georgios Mikellides Panayiota Michael Lilia Psalta Lilia Psalta Teresa Schuhmann Alexander T. Sack Alexander T. Sack |
| author_facet | Georgios Mikellides Georgios Mikellides Panayiota Michael Lilia Psalta Lilia Psalta Teresa Schuhmann Alexander T. Sack Alexander T. Sack |
| author_sort | Georgios Mikellides |
| collection | DOAJ |
| description | Depression is a common mental disorder that affects many people worldwide, while a significant proportion of patients remain non-responsive to antidepressant medications. Alternative treatment options such as ketamine therapy and repetitive transcranial magnetic stimulation (rTMS) therapy are offered nowadays. This study aims to describe and compare the acute antidepressive efficacy of both, intramuscular ketamine and rTMS in depression patients seeking help in a naturalistic clinical mental health setting. The clinical records of 24 patients with treatment resistant depression were collected from the clinical base of a real life clinic. Twelve patients were treated with intramuscular ketamine, twice weekly for 8 sessions, and twelve patients were treated with 30 sessions of left dorsolateral prefrontal cortex – intermittent theta-burst stimulation (DLPFC-iTBS). Using three clinical assessments (HDRS, HAM-A, BDI-II), our data reveal that both therapies led to significant improvement in symptoms from pre- to post- treatment, as well as that the two experimental groups did not differ significantly with respect to pre- to post- depressive and anxiety symptoms, indicating that the effect of both experimental groups in our sample was equally effective. Furthermore, our results showed high remission and response rates in both groups, with no statistical differences between the patients of ketamine group and rTMS group in remission and response rates. We show a significant pre- to post- treatment reduction in depressive and anxiety symptoms, with no significant differences between the two experimental groups, indicating that the effect of both therapies was equally effective in our limited sample. |
| first_indexed | 2024-04-11T16:52:25Z |
| format | Article |
| id | doaj.art-9b3d69b5c31c4f2aa1c7ebef780b92a1 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T16:52:25Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-9b3d69b5c31c4f2aa1c7ebef780b92a12022-12-22T04:13:24ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-01-011210.3389/fpsyt.2021.784830784830A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant DepressionGeorgios Mikellides0Georgios Mikellides1Panayiota Michael2Lilia Psalta3Lilia Psalta4Teresa Schuhmann5Alexander T. Sack6Alexander T. Sack7Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, NetherlandsCyprus rTMS Centre, Larnaca, CyprusCyprus rTMS Centre, Larnaca, CyprusDepartment of Psychology, University of Cyprus, Nicosia, CyprusSchool of Science, University of Central Lancashire, Preston, CyprusDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, NetherlandsDepartment of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, NetherlandsDepartment of Psychiatry and Neuropsychology, Brain + Nerve Centre, School for Mental Health and Neuroscience, Maastricht University Medical Centre+, Maastricht, NetherlandsDepression is a common mental disorder that affects many people worldwide, while a significant proportion of patients remain non-responsive to antidepressant medications. Alternative treatment options such as ketamine therapy and repetitive transcranial magnetic stimulation (rTMS) therapy are offered nowadays. This study aims to describe and compare the acute antidepressive efficacy of both, intramuscular ketamine and rTMS in depression patients seeking help in a naturalistic clinical mental health setting. The clinical records of 24 patients with treatment resistant depression were collected from the clinical base of a real life clinic. Twelve patients were treated with intramuscular ketamine, twice weekly for 8 sessions, and twelve patients were treated with 30 sessions of left dorsolateral prefrontal cortex – intermittent theta-burst stimulation (DLPFC-iTBS). Using three clinical assessments (HDRS, HAM-A, BDI-II), our data reveal that both therapies led to significant improvement in symptoms from pre- to post- treatment, as well as that the two experimental groups did not differ significantly with respect to pre- to post- depressive and anxiety symptoms, indicating that the effect of both experimental groups in our sample was equally effective. Furthermore, our results showed high remission and response rates in both groups, with no statistical differences between the patients of ketamine group and rTMS group in remission and response rates. We show a significant pre- to post- treatment reduction in depressive and anxiety symptoms, with no significant differences between the two experimental groups, indicating that the effect of both therapies was equally effective in our limited sample.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.784830/fulltreatment resistant depressionantidepressantsketamineIM ketaminerepetitive transcranial magnetic stimulationiTBS |
| spellingShingle | Georgios Mikellides Georgios Mikellides Panayiota Michael Lilia Psalta Lilia Psalta Teresa Schuhmann Alexander T. Sack Alexander T. Sack A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression Frontiers in Psychiatry treatment resistant depression antidepressants ketamine IM ketamine repetitive transcranial magnetic stimulation iTBS |
| title | A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression |
| title_full | A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression |
| title_fullStr | A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression |
| title_full_unstemmed | A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression |
| title_short | A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression |
| title_sort | retrospective naturalistic study comparing the efficacy of ketamine and repetitive transcranial magnetic stimulation for treatment resistant depression |
| topic | treatment resistant depression antidepressants ketamine IM ketamine repetitive transcranial magnetic stimulation iTBS |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.784830/full |
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