Assessment of insulin sensitivity/resistance
Insulin resistance is one pretty troublesome entity which very commonly aggravates metabolic syndrome. Many methods and indices are available for the estimation of insulin resistance. It is essential to test and validate their reliability before they can be used as an investigation in patients. At p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2015;volume=19;issue=1;spage=160;epage=164;aulast=Gutch |
| _version_ | 1828527907080765440 |
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| author | Manish Gutch Sukriti Kumar Syed Mohd Razi Kumar Keshav Gupta Abhinav Gupta |
| author_facet | Manish Gutch Sukriti Kumar Syed Mohd Razi Kumar Keshav Gupta Abhinav Gupta |
| author_sort | Manish Gutch |
| collection | DOAJ |
| description | Insulin resistance is one pretty troublesome entity which very commonly aggravates metabolic syndrome. Many methods and indices are available for the estimation of insulin resistance. It is essential to test and validate their reliability before they can be used as an investigation in patients. At present, hyperinsulinemic euglycemic clamp and intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance and are being used as a reference standard. Some simple methods, from which indices can be derived, have been validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). For the clinical uses HOMA-insulin resistance, QUIKI, and Matsuda are suitable, while HES, McAuley, Belfiore, Cederholm, Avignon and Stumvoll index are suitable for epidemiological/research purposes. With increasing number of these available indices of IR, it may be difficult for clinicians to select the most appropriate index for their studies. This review provides guidelines that must be considered before performing such studies. |
| first_indexed | 2024-12-11T21:44:41Z |
| format | Article |
| id | doaj.art-9b3d8011ecb24f64aea4ccdc8e3810e3 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-11T21:44:41Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-9b3d8011ecb24f64aea4ccdc8e3810e32022-12-22T00:49:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002015-01-0119116016410.4103/2230-8210.146874Assessment of insulin sensitivity/resistanceManish GutchSukriti KumarSyed Mohd RaziKumar Keshav GuptaAbhinav GuptaInsulin resistance is one pretty troublesome entity which very commonly aggravates metabolic syndrome. Many methods and indices are available for the estimation of insulin resistance. It is essential to test and validate their reliability before they can be used as an investigation in patients. At present, hyperinsulinemic euglycemic clamp and intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance and are being used as a reference standard. Some simple methods, from which indices can be derived, have been validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). For the clinical uses HOMA-insulin resistance, QUIKI, and Matsuda are suitable, while HES, McAuley, Belfiore, Cederholm, Avignon and Stumvoll index are suitable for epidemiological/research purposes. With increasing number of these available indices of IR, it may be difficult for clinicians to select the most appropriate index for their studies. This review provides guidelines that must be considered before performing such studies.http://www.ijem.in/article.asp?issn=2230-8210;year=2015;volume=19;issue=1;spage=160;epage=164;aulast=GutchHomeostasis model assessmenthyperinsulinemic euglycemic clampinsulin sensitivityquantitative insulin sensitivity check index |
| spellingShingle | Manish Gutch Sukriti Kumar Syed Mohd Razi Kumar Keshav Gupta Abhinav Gupta Assessment of insulin sensitivity/resistance Indian Journal of Endocrinology and Metabolism Homeostasis model assessment hyperinsulinemic euglycemic clamp insulin sensitivity quantitative insulin sensitivity check index |
| title | Assessment of insulin sensitivity/resistance |
| title_full | Assessment of insulin sensitivity/resistance |
| title_fullStr | Assessment of insulin sensitivity/resistance |
| title_full_unstemmed | Assessment of insulin sensitivity/resistance |
| title_short | Assessment of insulin sensitivity/resistance |
| title_sort | assessment of insulin sensitivity resistance |
| topic | Homeostasis model assessment hyperinsulinemic euglycemic clamp insulin sensitivity quantitative insulin sensitivity check index |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2015;volume=19;issue=1;spage=160;epage=164;aulast=Gutch |
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