Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes

Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes

Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusion in lymphocytes and mice lacking Syt7 have reduce...

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Bibliographic Details
Main Authors: Marwa Sleiman, David R. Stevens, Praneeth Chitirala, Jens Rettig
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
cytotoxic T lymphocytes
cytotoxic granules
granule fusion
granule trafficking
immune synapse
calcium dependence
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01080/full

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