Assessment of serum magnesium level in patients with bronchial asthma
Background: Asthma is one of the most common chronic diseases worldwide and has been increasing in prevalence over the last few decades. Magnesium ion has an inhibitory action on smooth muscle contraction, histamine release from mast cells and acetylcholine release from cholinergic nerve terminals....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-07-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763815201264 |
| _version_ | 1818853821122609152 |
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| author | Ahmad A. Ali Ramadan M. Bakr Maha Yousif Rania E. Foad |
| author_facet | Ahmad A. Ali Ramadan M. Bakr Maha Yousif Rania E. Foad |
| author_sort | Ahmad A. Ali |
| collection | DOAJ |
| description | Background: Asthma is one of the most common chronic diseases worldwide and has been increasing in prevalence over the last few decades. Magnesium ion has an inhibitory action on smooth muscle contraction, histamine release from mast cells and acetylcholine release from cholinergic nerve terminals. Magnesium has been shown to relax bronchial smooth muscles and influence the function of respiratory muscles. Hypomagnesemia have been associated with diminished respiratory muscle power.
Aim: To assess the serum Mg levels in bronchial asthma patients during stable and exacerbating clinical conditions.
Subjects and methods: 60 Subjects were enrolled, 40 patients diagnosed as bronchial asthma and 20 healthy individuals as a control group. The asthmatic patients were divided into group (I) chronic stable bronchial asthma and group (II) acute exacerbation of bronchial asthma.
Results: Serum Mg levels were significantly lower in asthmatic patients compared with healthy controls and significantly lower in asthmatic patients during exacerbation compared with stable asthmatics. There was a positive correlation between serum Mg levels and each of FEV1/FVC ratio and FEV1.
Conclusion: Hypomagnesemia was found in patients with chronic stable asthma and also in those with acute asthma exacerbation compared to control. Serum mg levels were significantly lower in asthmatic patients during exacerbations compared with stable asthmatics. |
| first_indexed | 2024-12-19T07:42:54Z |
| format | Article |
| id | doaj.art-9b3f87c307214bfebdedd64a1dde6344 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-19T07:42:54Z |
| publishDate | 2015-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-9b3f87c307214bfebdedd64a1dde63442022-12-21T20:30:25ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382015-07-0164353553910.1016/j.ejcdt.2015.04.010Assessment of serum magnesium level in patients with bronchial asthmaAhmad A. AliRamadan M. BakrMaha YousifRania E. FoadBackground: Asthma is one of the most common chronic diseases worldwide and has been increasing in prevalence over the last few decades. Magnesium ion has an inhibitory action on smooth muscle contraction, histamine release from mast cells and acetylcholine release from cholinergic nerve terminals. Magnesium has been shown to relax bronchial smooth muscles and influence the function of respiratory muscles. Hypomagnesemia have been associated with diminished respiratory muscle power. Aim: To assess the serum Mg levels in bronchial asthma patients during stable and exacerbating clinical conditions. Subjects and methods: 60 Subjects were enrolled, 40 patients diagnosed as bronchial asthma and 20 healthy individuals as a control group. The asthmatic patients were divided into group (I) chronic stable bronchial asthma and group (II) acute exacerbation of bronchial asthma. Results: Serum Mg levels were significantly lower in asthmatic patients compared with healthy controls and significantly lower in asthmatic patients during exacerbation compared with stable asthmatics. There was a positive correlation between serum Mg levels and each of FEV1/FVC ratio and FEV1. Conclusion: Hypomagnesemia was found in patients with chronic stable asthma and also in those with acute asthma exacerbation compared to control. Serum mg levels were significantly lower in asthmatic patients during exacerbations compared with stable asthmatics.http://www.sciencedirect.com/science/article/pii/S0422763815201264MagnesiumBronchial asthmaStableExacerbation |
| spellingShingle | Ahmad A. Ali Ramadan M. Bakr Maha Yousif Rania E. Foad Assessment of serum magnesium level in patients with bronchial asthma Egyptian Journal of Chest Disease and Tuberculosis Magnesium Bronchial asthma Stable Exacerbation |
| title | Assessment of serum magnesium level in patients with bronchial asthma |
| title_full | Assessment of serum magnesium level in patients with bronchial asthma |
| title_fullStr | Assessment of serum magnesium level in patients with bronchial asthma |
| title_full_unstemmed | Assessment of serum magnesium level in patients with bronchial asthma |
| title_short | Assessment of serum magnesium level in patients with bronchial asthma |
| title_sort | assessment of serum magnesium level in patients with bronchial asthma |
| topic | Magnesium Bronchial asthma Stable Exacerbation |
| url | http://www.sciencedirect.com/science/article/pii/S0422763815201264 |
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