Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity

Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity

RORγT is a protein product of the RORC gene belonging to the nuclear receptor subfamily of retinoic-acid-receptor-related orphan receptors (RORs). RORγT is preferentially expressed in Th17 lymphocytes and drives their differentiation from naive CD4+ cells and is involved in the regulation of the exp...

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Bibliographic Details
Main Authors: Joanna Pastwińska, Kaja Karaś, Anna Sałkowska, Iwona Karwaciak, Katarzyna Chałaśkiewicz, Błażej A. Wojtczak, Rafał A. Bachorz, Marcin Ratajewski
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
RORgammaT
RORC
Th17
inverse agonist
corosolic acid
oleanolic acid
Online Access:https://www.mdpi.com/1422-0067/23/3/1906

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