Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation

Development and In Vivo Application of a Water-Soluble Anticancer Copper Ionophore System Using a Temperature-Sensitive Liposome Formulation

Liposomes containing copper and the copper ionophore neocuproine were prepared and characterized for in vitro and in vivo anticancer activity. Thermosensitive PEGylated liposomes were prepared with different molar ratios of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) and hydrogenated soy...

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Bibliographic Details
Main Authors: Anikó Gaál, Tamás M. Garay, Ildikó Horváth, Domokos Máthé, Dávid Szöllősi, Dániel S. Veres, Jeremiah Mbuotidem, Tibor Kovács, József Tóvári, Ralf Bergmann, Christina Streli, Gergely Szakács, Judith Mihály, Zoltán Varga, Norbert Szoboszlai
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
neocuproine
themosensitive liposomal formulation
mild hyperthermia
copper nanotoxin
MRPS
in vivo antitumor effect
Online Access:https://www.mdpi.com/1999-4923/12/5/466

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