New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and Protective against Leishmania infantum Challenge

New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and Protective against Leishmania infantum Challenge

Visceral leishmaniasis (VL) is a major public health issue reported as the second illness in mortality among all tropical diseases. Clinical trials have shown that protection against VL is associated with robust T cell responses, especially those producing IFN-γ. The Leishmania amastigote 2 (A2) pro...

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Bibliographic Details
Main Authors: Ana Paula M. M. Almeida, Leopoldo F. M. Machado, Daniel Doro, Frederico C. Nascimento, Leonardo Damasceno, Ricardo Tostes Gazzinelli, Ana Paula Fernandes, Caroline Junqueira
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
visceral leishmaniasis
vaccine
Trypanosoma cruzi CL-14
Leishmania infantum
amastigote 2
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00465/full

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