Review of selective accumudation of photosensitizers with different chemical structure in tumor tissue
The review of available theories explaining mechanisms of photosensitizer selective accumulation in tumor tissue is represented in the article. Variants associated with both targeted delivery of compounds with different chemical structure to tumor and low elimination rate of photosensitizers in the...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2013-12-01
|
| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | https://www.pdt-journal.com/jour/article/view/24 |
| _version_ | 1797883722408656896 |
|---|---|
| author | E. A. Machinskaya V. I. Ivanova-Radkevich |
| author_facet | E. A. Machinskaya V. I. Ivanova-Radkevich |
| author_sort | E. A. Machinskaya |
| collection | DOAJ |
| description | The review of available theories explaining mechanisms of photosensitizer selective accumulation in tumor tissue is represented in the article. Variants associated with both targeted delivery of compounds with different chemical structure to tumor and low elimination rate of photosensitizers in the tumor are described. Details of tumor cell up-take of photosensitizer bounded with lipoproteins due to increased expression of low solidity lipoproteins receptors comparing with normal cells; mechanisms of photosensitizer accumulation in tumor tissue due to phagocytosis by macrophages localized in this area; mechanisms of binding of porphyrin-based photosensitizer by collagen fibers, production of which is increased in tumor cells, and other mechanisms are reviewed. Perspectives of practical application of knowledge about mechanisms of selective accumulation for induced increase in selectiveness of photosensitizer accumulation in tumor through targeted delivery of agent to pathological tissues are shown. Analysis of world trends in the search of transport systems for photosensitizers is performed. |
| first_indexed | 2024-04-10T03:55:11Z |
| format | Article |
| id | doaj.art-9b41a1b8e2344c1db472433fed39458a |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-04-10T03:55:11Z |
| publishDate | 2013-12-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-9b41a1b8e2344c1db472433fed39458a2023-03-13T07:12:29ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322013-12-0124283224Review of selective accumudation of photosensitizers with different chemical structure in tumor tissueE. A. Machinskaya0V. I. Ivanova-Radkevich1Научно-исследовательский институт органических полупродуктов и красителей, Москва, РоссияРоссийский Университет дружбы народов, Москва, Россия; Научно-исследовательский институт органических полупродуктов и красителей, Москва, РоссияThe review of available theories explaining mechanisms of photosensitizer selective accumulation in tumor tissue is represented in the article. Variants associated with both targeted delivery of compounds with different chemical structure to tumor and low elimination rate of photosensitizers in the tumor are described. Details of tumor cell up-take of photosensitizer bounded with lipoproteins due to increased expression of low solidity lipoproteins receptors comparing with normal cells; mechanisms of photosensitizer accumulation in tumor tissue due to phagocytosis by macrophages localized in this area; mechanisms of binding of porphyrin-based photosensitizer by collagen fibers, production of which is increased in tumor cells, and other mechanisms are reviewed. Perspectives of practical application of knowledge about mechanisms of selective accumulation for induced increase in selectiveness of photosensitizer accumulation in tumor through targeted delivery of agent to pathological tissues are shown. Analysis of world trends in the search of transport systems for photosensitizers is performed.https://www.pdt-journal.com/jour/article/view/24фотосенсибилизаторыселективное накоплениехимическая структура |
| spellingShingle | E. A. Machinskaya V. I. Ivanova-Radkevich Review of selective accumudation of photosensitizers with different chemical structure in tumor tissue Biomedical Photonics фотосенсибилизаторы селективное накопление химическая структура |
| title | Review of selective accumudation of photosensitizers with different chemical structure in tumor tissue |
| title_full | Review of selective accumudation of photosensitizers with different chemical structure in tumor tissue |
| title_fullStr | Review of selective accumudation of photosensitizers with different chemical structure in tumor tissue |
| title_full_unstemmed | Review of selective accumudation of photosensitizers with different chemical structure in tumor tissue |
| title_short | Review of selective accumudation of photosensitizers with different chemical structure in tumor tissue |
| title_sort | review of selective accumudation of photosensitizers with different chemical structure in tumor tissue |
| topic | фотосенсибилизаторы селективное накопление химическая структура |
| url | https://www.pdt-journal.com/jour/article/view/24 |
| work_keys_str_mv | AT eamachinskaya reviewofselectiveaccumudationofphotosensitizerswithdifferentchemicalstructureintumortissue AT viivanovaradkevich reviewofselectiveaccumudationofphotosensitizerswithdifferentchemicalstructureintumortissue |